GBPI-1 Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. Belongs to the PP1 inhibitor family. Detected in colon, intestine, kidney and brain cortex. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 2|2 E5
Cellular Component:  cytoplasm
Molecular Function:  protein phosphatase inhibitor activity; protein serine/threonine phosphatase inhibitor activity
Biological Process:  negative regulation of protein serine/threonine phosphatase activity; positive regulation of protein serine/threonine phosphatase activity; regulation of phosphorylation
Reference #:  Q7TT52 (UniProtKB)
Alt. Names/Synonyms: 2010107K19Rik; Gastrointestinal and brain-specific PP1-inhibitory protein 1; Gbpi; GBPI-1; OTTMUSP00000016929; PKC-dependent PP1 inhibitory protein subunit 14; PP14D; Ppp1r14; Ppp1r14d; Protein phosphatase 1 regulatory subunit 14D; protein phosphatase 1, regulatory (inhibitor) subunit 14D; protein phosphatase 1, regulatory inhibitor subunit 14D
Gene Symbols: Ppp1r14d
Molecular weight: 16,817 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
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GBPI-1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene