GBPI-1
Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. Belongs to the PP1 inhibitor family. Detected in colon, intestine, kidney and brain cortex. Note: This description may include information from UniProtKB.
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Protein type: Inhibitor; Protein phosphatase, regulatory subunit |
Chromosomal Location of human Ortholog: 15q15.1 |
Cellular Component:
cytoplasm
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Molecular Function:
protein serine/threonine phosphatase inhibitor activity
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Biological Process:
negative regulation of protein serine/threonine phosphatase activity; positive regulation of protein serine/threonine phosphatase activity; regulation of phosphorylation
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Reference #:
Q9NXH3
(UniProtKB)
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Alt. Names/Synonyms: CPI17-like; FLJ20251; Gastrointestinal and brain-specific PP1-inhibitory protein 1; GBPI; GBPI-1; GBPI1; gut and brain phosphatase inhibitor 1; MGC119014; MGC119016; PKC-dependent PP1 inhibitory protein; PP14D; PPP1R14D; protein phosphatase 1 regulatory inhibitor subunit 14D; Protein phosphatase 1 regulatory subunit 14D; protein phosphatase 1, regulatory (inhibitor) subunit 14D
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Gene Symbols: PPP1R14D
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Molecular weight:
16,508 Da
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Basal Isoelectric point:
7.72
Predict pI for various phosphorylation states
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