GBPI-1 Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. Belongs to the PP1 inhibitor family. Detected in colon, intestine, kidney and brain cortex. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Protein phosphatase, regulatory subunit
Chromosomal Location of human Ortholog: 15q15.1
Cellular Component:  cytoplasm
Molecular Function:  protein serine/threonine phosphatase inhibitor activity
Biological Process:  negative regulation of protein serine/threonine phosphatase activity; positive regulation of protein serine/threonine phosphatase activity; regulation of phosphorylation
Reference #:  Q9NXH3 (UniProtKB)
Alt. Names/Synonyms: CPI17-like; FLJ20251; Gastrointestinal and brain-specific PP1-inhibitory protein 1; GBPI; GBPI-1; GBPI1; gut and brain phosphatase inhibitor 1; MGC119014; MGC119016; PKC-dependent PP1 inhibitory protein; PP14D; PPP1R14D; protein phosphatase 1 regulatory inhibitor subunit 14D; Protein phosphatase 1 regulatory subunit 14D; protein phosphatase 1, regulatory (inhibitor) subunit 14D
Gene Symbols: PPP1R14D
Molecular weight: 16,508 Da
Basal Isoelectric point: 7.72  Predict pI for various phosphorylation states
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GBPI-1

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein