CDH2 Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 18q12.1
Cellular Component:  apical plasma membrane; basolateral plasma membrane; catenin complex; cell junction; cell surface; cell-cell adherens junction; cell-cell junction; cytoplasm; endoplasmic reticulum lumen; fascia adherens; integral component of plasma membrane; intercalated disc; lamellipodium; plasma membrane; plasma membrane raft; sarcolemma
Molecular Function:  alpha-catenin binding; beta-catenin binding; calcium ion binding; gamma-catenin binding; protein binding; protein kinase binding; protein phosphatase binding
Biological Process:  adherens junction organization; brain morphogenesis; cell adhesion; cell migration; cell-cell adhesion; cell-cell adhesion mediated by cadherin; cellular protein metabolic process; cerebral cortex development; glial cell differentiation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homeostasis of number of cells; negative regulation of canonical Wnt signaling pathway; neuroepithelial cell differentiation; neuroligin clustering involved in postsynaptic membrane assembly; neuronal stem cell population maintenance; positive regulation of MAPK cascade; positive regulation of muscle cell differentiation; positive regulation of synaptic vesicle clustering; post-translational protein modification; protein localization to plasma membrane; radial glial cell differentiation; regulation of oligodendrocyte progenitor proliferation; regulation of postsynaptic density protein 95 clustering; striated muscle cell differentiation
Disease: Agenesis Of Corpus Callosum, Cardiac, Ocular, And Genital Syndrome; Arrhythmogenic Right Ventricular Dysplasia, Familial, 14
Reference #:  P19022 (UniProtKB)
Alt. Names/Synonyms: ACOGS; ARVD14; CADH2; cadherin 2; cadherin 2, N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal); Cadherin-2; calcium-dependent adhesion protein, neuronal; CD325; CDH2; CDHN; CDw325; N Cadherin; N-cadherin; N-cadherin 1; NCAD; Neural cadherin; neural-cadherin
Gene Symbols: CDH2
Molecular weight: 99,809 Da
Basal Isoelectric point: 4.64  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB