IL2RB Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15. Belongs to the type I cytokine receptor family. Type 4 subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 15 E1|15 37.52 cM
Cellular Component:  cell surface; external side of plasma membrane; integral component of membrane; membrane; plasma membrane
Molecular Function:  cytokine receptor activity; interleukin-15 receptor activity; interleukin-2 binding; interleukin-2 receptor activity
Biological Process:  cytokine-mediated signaling pathway; interleukin-15-mediated signaling pathway; natural killer cell activation; negative regulation of apoptotic process; positive regulation of phagocytosis
Reference #:  P16297 (UniProtKB)
Alt. Names/Synonyms: CD122; High affinity IL-2 receptor subunit beta; IL-15 receptor beta chain; IL-15Rbeta; IL-2 receptor beta chain; IL-2 receptor subunit beta; IL-2/15 receptor-beta; Il-2/15Rbeta; IL-2R subunit beta; IL-2RB; Il-2Rbeta; IL15Rbeta; Il2rb; interleukin 2 receptor, beta chain; Interleukin-2 receptor subunit beta; MGC118674; p70; p70-75
Gene Symbols: Il2rb
Molecular weight: 60,539 Da
Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states
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IL2RB

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene