IL-1RA Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells. Belongs to the interleukin-1 receptor family. Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 1 B|1 18.81 cM
Cellular Component:  axon; cell surface; external side of plasma membrane; extracellular region; extracellular space; integral component of membrane; membrane; nucleus; plasma membrane; postsynaptic density; protein-containing complex
Molecular Function:  interleukin-1 binding; interleukin-1 receptor activity; interleukin-1, type I, activating receptor activity; ionotropic glutamate receptor binding; platelet-derived growth factor receptor binding; protease binding; protein binding
Biological Process:  cytokine-mediated signaling pathway; heat acclimation; inflammatory response; interleukin-1-mediated signaling pathway; positive regulation of interferon-gamma production; positive regulation of interleukin-1-mediated signaling pathway; positive regulation of neuron migration; positive regulation of neutrophil extravasation; positive regulation of T-helper 1 cell cytokine production; regulation of inflammatory response; response to interleukin-1; response to radiation; signal transduction
Reference #:  P13504 (UniProtKB)
Alt. Names/Synonyms: CD121 antigen-like family member A; CD121a; CD121b; IL-1 receptor alpha chain; IL-1R-1; IL-1R-alpha; Il-1r1; IL-1RT-1; IL-1RT1; IL-iR; Il1r-1; Il1r1; Il1ra; interleukin 1 receptor, type I; Interleukin-1 receptor alpha; Interleukin-1 receptor type 1; Interleukin-1 receptor type I; MGC129154; p80
Gene Symbols: Il1r1
Molecular weight: 66,698 Da
Basal Isoelectric point: 6.41  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene