EHD1 ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes. Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth. Plays a role in myoblast fusion. Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing. Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily. Highly expressed in testis. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Vesicle
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component:  ciliary pocket membrane; early endosome membrane; endosome membrane; lipid droplet; plasma membrane; platelet dense tubular network membrane; recycling endosome membrane
Molecular Function:  ATP binding; calcium ion binding; GTP binding; identical protein binding; protein binding; Rab GTPase binding
Biological Process:  blood coagulation; cellular response to nerve growth factor stimulus; cholesterol homeostasis; cilium assembly; endocytic recycling; endocytosis; intracellular protein transport; low-density lipoprotein particle clearance; neuron projection development; positive regulation of cholesterol storage; positive regulation of endocytic recycling; positive regulation of myoblast fusion; protein homooligomerization; protein localization to cilium
Reference #:  Q9H4M9 (UniProtKB)
Alt. Names/Synonyms: EH domain-containing protein 1; EH-domain containing 1; EHD1; FLJ42622; FLJ44618; H-PAST; hPAST1; PAST; PAST homolog 1; PAST1; Testilin
Gene Symbols: EHD1
Molecular weight: 60,627 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene