IL13R Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity. Belongs to the type I cytokine receptor family. Type 5 subfamily. Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: X A3.3|X 20.49 cM
Cellular Component:  external side of plasma membrane; integral component of membrane; membrane; receptor complex
Molecular Function:  cytokine binding; cytokine receptor activity; interleukin-13 receptor activity
Reference #:  O09030 (UniProtKB)
Alt. Names/Synonyms: AI882074; CD213a; CD213a1; I13R1; IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; IL-13R-alpha-1; IL-13r[a]; IL-13RA1; Il13r; Il13ra; Il13ra1; interleukin 13 receptor, alpha 1; Interleukin-13 receptor subunit alpha-1; Interleukin-13-binding protein; Novel cytokine receptor 4; NR4; OTTMUSP00000018722
Gene Symbols: Il13ra1
Molecular weight: 48,402 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
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IL13R

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene