ARPC3 Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Belongs to the ARPC3 family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q24.11
Cellular Component:  actin cytoskeleton; Arp2/3 protein complex; cytosol; filamentous actin; growth cone leading edge; lamellipodium; nucleus; site of double-strand break
Molecular Function:  protein binding; structural constituent of cytoskeleton
Biological Process:  actin polymerization-dependent cell motility; Arp2/3 complex-mediated actin nucleation; cellular response to nerve growth factor stimulus; ephrin receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; membrane organization
Reference #:  O15145 (UniProtKB)
Alt. Names/Synonyms: actin related protein 2/3 complex, subunit 3, 21kDa; Actin-related protein 2/3 complex subunit 3; ARC21; Arp2/3 complex 21 kDa subunit; ARP2/3 protein complex subunit p21; ARPC3; p21-ARC
Gene Symbols: ARPC3
Molecular weight: 20,547 Da
Basal Isoelectric point: 8.78  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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