IQGAP1 Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest. Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Ras; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 15q26.1
Cellular Component:  actin filament; axon; cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; extrinsic component of cytoplasmic side of plasma membrane; growth cone; lateral plasma membrane; membrane raft; microtubule; midbody; neuron projection; nucleus; plasma membrane; ruffle; secretory granule membrane; slit diaphragm
Molecular Function:  calcium ion binding; calmodulin binding; GTPase activator activity; GTPase inhibitor activity; mitogen-activated protein kinase binding; molecular adaptor activity; phosphatidylinositol-3,4,5-trisphosphate binding; protein binding; protein domain specific binding; protein kinase binding; protein phosphatase binding; protein serine/threonine kinase activator activity; protein-containing complex binding; Rac GTPase binding; S100 protein binding; small GTPase binding
Biological Process:  cell migration; cellular response to calcium ion; cellular response to epidermal growth factor stimulus; cellular response to platelet-derived growth factor stimulus; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; glomerular visceral epithelial cell development; negative regulation of dephosphorylation; negative regulation of GTPase activity; neuron projection extension; neutrophil degranulation; platelet-derived growth factor receptor signaling pathway; positive regulation of cellular protein localization; positive regulation of dendrite development; positive regulation of focal adhesion assembly; positive regulation of GTPase activity; positive regulation of MAP kinase activity; positive regulation of peptidyl-tyrosine autophosphorylation; positive regulation of protein kinase activity; positive regulation of vascular associated smooth muscle cell migration; regulation of cytokine production; regulation of mitotic cell cycle; response to angiotensin; signal transduction; viral process
Reference #:  P46940 (UniProtKB)
Alt. Names/Synonyms: HUMORFA01; IQ motif containing GTPase activating protein 1; IQGA1; IQGAP1; KIAA0051; p195; Ras GTPase-activating-like protein IQGAP1; RasGAP-like with IQ motifs; SAR1
Gene Symbols: IQGAP1
Molecular weight: 189,252 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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