PGAM1 Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. Expressed in the liver and brain. Not found in the muscle. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 3.1.3.13; EC 5.4.2.11; EC 5.4.2.4; Isomerase; Phosphatase (non-protein)
Chromosomal Location of Human Ortholog: 10q24.1
Cellular Component:  cytoplasm; cytosol; extracellular region; ficolin-1-rich granule lumen; nucleus; secretory granule lumen
Molecular Function:  bisphosphoglycerate mutase activity; hydrolase activity; phosphoglycerate mutase activity; protein binding; protein kinase binding
Biological Process:  canonical glycolysis; gluconeogenesis; glycolytic process; neutrophil degranulation; regulation of glycolytic process; regulation of pentose-phosphate shunt; respiratory burst
Reference #:  P18669 (UniProtKB)
Alt. Names/Synonyms: BPG-dependent PGAM 1; epididymis secretory protein Li 35; HEL-S-35; PGAM-B; PGAM1; PGAMA; Phosphoglycerate mutase 1; phosphoglycerate mutase 1 (brain); phosphoglycerate mutase A, nonmuscle form; Phosphoglycerate mutase isozyme B
Gene Symbols: PGAM1
Molecular weight: 28,804 Da
Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PGAM1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene