IKKB Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.10; IKK family; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 8p11.21
Cellular Component:  CD40 receptor complex; cytoplasmic side of plasma membrane; cytosol; IkappaB kinase complex; membrane raft; nucleus
Molecular Function:  ATP binding; identical protein binding; IkappaB kinase activity; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; scaffold protein binding
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cellular response to tumor necrosis factor; cortical actin cytoskeleton organization; Fc-epsilon receptor signaling pathway; I-kappaB kinase/NF-kappaB signaling; I-kappaB phosphorylation; inflammatory response; innate immune response; interleukin-1-mediated signaling pathway; MyD88-independent toll-like receptor signaling pathway; negative regulation of apoptotic process; negative regulation of bicellular tight junction assembly; negative regulation of myosin-light-chain-phosphatase activity; peptidyl-serine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein localization to plasma membrane; protein phosphorylation; regulation of establishment of endothelial barrier; regulation of phosphorylation; regulation of tumor necrosis factor-mediated signaling pathway; response to virus; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; viral process
Disease: Immunodeficiency 15; Immunodeficiency 15a
Reference #:  O14920 (UniProtKB)
Alt. Names/Synonyms: FLJ40509; I-kappa-B kinase 2; I-kappa-B-kinase beta; IkappaB kinase; IKBKB; IKK-B; IKK-beta; IKK2; IKKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; Inhibitor of nuclear factor kappa-B kinase subunit beta; MGC131801; NFKBIKB; Nuclear factor NF-kappa-B inhibitor kinase beta
Gene Symbols: IKBKB
Molecular weight: 86,564 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  NF-kB Signaling  |  T Cell Receptor Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IKKB

Protein Structure Not Found.


Substrate Sequence Logo
Open Substrate Page

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein