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MBP
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. Belongs to the myelin basic protein family. MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal |
| Chromosomal Location of mouse Ortholog: 18 E3|18 55.84 cM |
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Cellular Component:
cell periphery; cell projection; cell surface; compact myelin; cytoplasm; internode region of axon; membrane; myelin sheath; neuronal cell body; nucleus; plasma membrane; protein-containing complex
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Molecular Function:
calmodulin binding; lipid binding; protease binding; structural constituent of myelin sheath
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Biological Process:
maintenance of blood-brain barrier; MAPK cascade; membrane organization; myelination; negative regulation of axonogenesis; negative regulation of heterotypic cell-cell adhesion; positive regulation of chemokine (C-X-C motif) ligand 2 production; positive regulation of interleukin-6 production; positive regulation of metalloendopeptidase activity; response to progesterone; response to toxic substance; sensory perception of sound
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Reference #:
P04370
(UniProtKB)
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Alt. Names/Synonyms: C76307; goll; Golli-Mbp; Hmb; Hmbpr; jve; MBP; mld; Myelin A1 protein; Myelin basic protein; myelin basic protein transcript variant X5; myelin deficient; OTTMUSP00000017514; OTTMUSP00000017515; R75289; Shi; shiverer
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Gene Symbols: Mbp
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Molecular weight:
27,168 Da
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Basal Isoelectric point:
9.58
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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