IRSp53 Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component:  cytoplasm; cytosol; dendritic shaft; dendritic spine cytoplasm; excitatory synapse; filopodium; glutamatergic synapse; Golgi apparatus; microtubule; neuron projection branch point; neuron projection terminus; neuronal cell body; plasma membrane; postsynaptic cytosol; postsynaptic density, intracellular component; presynaptic cytosol; rough endoplasmic reticulum; ruffle; Schaffer collateral - CA1 synapse; secretory granule; synaptic membrane
Molecular Function:  cytoskeletal adaptor activity; identical protein binding; PDZ domain binding; proline-rich region binding; protein binding; protein C-terminus binding; scaffold protein binding; transcription cofactor binding
Biological Process:  actin crosslink formation; actin filament bundle assembly; axonogenesis; brain development; cell-cell adhesion; cellular response to epidermal growth factor stimulus; cellular response to L-glutamate; dendrite development; Fc-gamma receptor signaling pathway involved in phagocytosis; insulin receptor signaling pathway; modification of synaptic structure, modulating synaptic transmission; plasma membrane organization; positive regulation of dendritic spine morphogenesis; positive regulation of excitatory postsynaptic potential; protein localization to synapse; regulation of actin cytoskeleton organization; regulation of cell shape; regulation of modification of postsynaptic actin cytoskeleton; regulation of synaptic plasticity; response to bacterium; vascular endothelial growth factor receptor signaling pathway
Reference #:  Q9UQB8 (UniProtKB)
Alt. Names/Synonyms: BAI-associated protein 2; BAI1-associated protein 2; BAIAP2; BAIP2; BAP2; Brain-specific angiogenesis inhibitor 1-associated protein 2; Fas ligand-associated factor 3; FLAF3; Insulin receptor substrate p53; Insulin receptor substrate p53/p58; Insulin receptor substrate protein of 53 kDa; IRS-58; IRSp53; IRSp53/58; Protein BAP2
Gene Symbols: BAIAP2
Molecular weight: 60,868 Da
Basal Isoelectric point: 8.99  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Select Structure to View Below

IRSp53

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein