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ZNF289
GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GAP; GAP, ARF |
| Chromosomal Location of human Ortholog: 11p11.2 |
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Cellular Component:
cytosol; Golgi apparatus; Golgi membrane; plasma membrane
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Molecular Function:
GTPase activator activity; metal ion binding
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Biological Process:
COPI coating of Golgi vesicle; protein transport
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Reference #:
Q8N6H7
(UniProtKB)
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Alt. Names/Synonyms: ADP ribosylation factor GTPase activating protein 2; ADP-ribosylation factor GTPase activating protein 2; ADP-ribosylation factor GTPase-activating protein 2; ARF GAP 2; ARFG2; ARFGAP2; FLJ14576; FLJ26000; GTPase-activating protein ZNF289; IRZ; Nbla10535; putative protein product of Nbla10535; Zfp289; Zinc finger protein 289; zinc finger protein 289, ID1 regulated; ZNF289
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Gene Symbols: ARFGAP2
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Molecular weight:
56,720 Da
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Basal Isoelectric point:
8.08
Predict pI for various phosphorylation states
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