ZNF289 GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, ARF
Chromosomal Location of Human Ortholog: 11p11.2
Cellular Component:  cytosol; Golgi apparatus; Golgi membrane; plasma membrane
Molecular Function:  metal ion binding
Biological Process:  ER to Golgi vesicle-mediated transport; positive regulation of GTPase activity; protein transport; retrograde vesicle-mediated transport, Golgi to ER
Reference #:  Q8N6H7 (UniProtKB)
Alt. Names/Synonyms: ADP-ribosylation factor GTPase activating protein 2; ADP-ribosylation factor GTPase-activating protein 2; ARF GAP 2; ARFG2; ARFGAP2; FLJ14576; FLJ26000; GTPase-activating protein ZNF289; IRZ; Nbla10535; putative protein product of Nbla10535; Zfp289; Zinc finger protein 289; zinc finger protein 289, ID1 regulated; ZNF289
Gene Symbols: ARFGAP2
Molecular weight: 56,720 Da
Basal Isoelectric point: 8.08  Predict pI for various phosphorylation states
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ZNF289

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein