MGRN1 E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; EC 6.3.2.-; EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component:  cytoplasm; cytosol; early endosome; nucleus; plasma membrane
Molecular Function:  metal ion binding; protein binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity
Biological Process:  endosome to lysosome transport; negative regulation of cAMP-mediated signaling; negative regulation of G protein-coupled receptor signaling pathway; negative regulation of smoothened signaling pathway; protein monoubiquitination; protein polyubiquitination
Reference #:  O60291 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin-protein ligase MGRN1; KIAA0544; mahogunin ring finger 1; mahogunin ring finger 1, E3 ubiquitin protein ligase; Mahogunin RING finger protein 1; mahogunin, ring finger 1; MGRN1; Probable E3 ubiquitin-protein ligase MGRN1; RING finger protein 156; RING-type E3 ubiquitin transferase MGRN1; RNF156
Gene Symbols: MGRN1
Molecular weight: 60,753 Da
Basal Isoelectric point: 5.01  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein