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MGRN1
E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of human Ortholog: 16p13.3 |
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Cellular Component:
cytoplasm; cytosol; early endosome; endoplasmic reticulum; intracellular membrane-bounded organelle; nucleus; plasma membrane
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Molecular Function:
metal ion binding; protein binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity
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Biological Process:
endosome to lysosome transport; negative regulation of cAMP-mediated signaling; negative regulation of G protein-coupled receptor signaling pathway; negative regulation of smoothened signaling pathway; protein monoubiquitination; protein polyubiquitination; protein ubiquitination
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Reference #:
O60291
(UniProtKB)
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Alt. Names/Synonyms: E3 ubiquitin-protein ligase MGRN1; KIAA0544; mahogunin ring finger 1; mahogunin ring finger 1, E3 ubiquitin protein ligase; Mahogunin RING finger protein 1; mahogunin, ring finger 1; MGRN1; Probable E3 ubiquitin-protein ligase MGRN1; RING finger protein 156; RING-type E3 ubiquitin transferase MGRN1; RNF156
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Gene Symbols: MGRN1
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Molecular weight:
60,753 Da
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Basal Isoelectric point:
5.01
Predict pI for various phosphorylation states
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