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Rin1
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. Belongs to the RIN (Ras interaction/interference) family. Expressed in all tissues examined with high levels in brain, placenta and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GEF; GEF, Rab |
| Chromosomal Location of human Ortholog: 11q13.2 |
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Cellular Component:
cytoplasm; cytoskeleton; cytosol; endocytic vesicle; plasma membrane
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Molecular Function:
GTPase activator activity; guanyl-nucleotide exchange factor activity; protein binding; small GTPase binding
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Biological Process:
endocytosis; signal transduction
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Reference #:
Q13671
(UniProtKB)
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Alt. Names/Synonyms: Ras and Rab interactor 1; ras inhibitor 1; Ras inhibitor JC99; ras inhibitor RIN1; Ras interaction/interference protein 1; RIN1
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Gene Symbols: RIN1
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Molecular weight:
84,099 Da
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Basal Isoelectric point:
8.3
Predict pI for various phosphorylation states
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