Rin1 Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. Belongs to the RIN (Ras interaction/interference) family. Expressed in all tissues examined with high levels in brain, placenta and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rab
Chromosomal Location of human Ortholog: 11q13.2
Cellular Component:  cytoplasm; cytoskeleton; cytosol; endocytic vesicle; plasma membrane
Molecular Function:  GTPase activator activity; guanyl-nucleotide exchange factor activity; protein binding; small GTPase binding
Biological Process:  endocytosis; signal transduction
Reference #:  Q13671 (UniProtKB)
Alt. Names/Synonyms: Ras and Rab interactor 1; ras inhibitor 1; Ras inhibitor JC99; ras inhibitor RIN1; Ras interaction/interference protein 1; RIN1
Gene Symbols: RIN1
Molecular weight: 84,099 Da
Basal Isoelectric point: 8.3  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein