RAP1A Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. Belongs to the small GTPase superfamily. Ras family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of human Ortholog: 1p13.2
Cellular Component:  cell junction; cytoplasm; cytosol; early endosome; glutamatergic synapse; guanyl-nucleotide exchange factor complex; late endosome; neuron projection; perinuclear region of cytoplasm; phagocytic vesicle; plasma membrane; specific granule membrane
Molecular Function:  GTP binding; GTPase activity; protein binding; protein-containing complex binding; Rap guanyl-nucleotide exchange factor activity
Biological Process:  cellular response to cAMP; cellular response to drug; cellular response to glucose stimulus; cellular response to nerve growth factor stimulus; establishment of endothelial barrier; liver regeneration; negative regulation of collagen biosynthetic process; negative regulation of synaptic vesicle exocytosis; nerve growth factor signaling pathway; neutrophil degranulation; positive regulation of ERK1 and ERK2 cascade; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis; positive regulation of glucose import; positive regulation of GTPase activity; positive regulation of neuron projection development; positive regulation of protein kinase activity; positive regulation of vasculogenesis; protein localization to plasma membrane; Rap protein signal transduction; regulation of cell junction assembly; regulation of insulin secretion; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; response to antineoplastic agent
Reference #:  P62834 (UniProtKB)
Alt. Names/Synonyms: C21KG; G-22K; GTP-binding protein smg p21A; KREV-1; KREV1; RAP1; RAP1A; RAP1A, member of RAS oncogene family; Ras-related protein Krev-1; Ras-related protein Rap-1A; RAS-related protein RAP1A; SMGP21
Gene Symbols: RAP1A
Molecular weight: 20,987 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene