Abl an ubiquitous and highly conserved, proto-oncogenic non-receptor tyrosine kinase that plays a role in many key processes including cell growth and survival, actin remodeling, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Negatively regulated by its SH3 domain. Deletion of the SH3 domain turns ABL1 into an oncogene. The Philadelphia chromosome translocation t(9;22)(q34;q11) creates a Bcr-Abl fusion protein, responsible for 90% of chronic myelogenous leukemia (CML) and ~25% of acute lymphoblastic leukemia (ALL). Is inhibited by active-site binding small molecules such as imatinib (Gleevec), Dasatinib, Nilotinib, Bosutinib, Ponatinib, and Bafetinib. Compounds such as GNF-2 that bind the myristate-binding pocket of Abl allosterically inhibit Abl kinase activity. Modulates the endocytosis of activated B-cell receptor complexes. Regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Mitochondrial dysfunction and cell death in response to oxidative stress. Translocates to the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Regulates T-cell differentiation in a TBX21-dependent manner. Two alternatively-spliced human isoforms have been described: one that is N-terminally myristoylated and the other not due to an alternative splicing of the first exon. Note: This description may include information from UniProtKB.
Protein type: Abl family; EC; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of human Ortholog: 9q34.12
Cellular Component:  actin cytoskeleton; cytoplasm; cytosol; dendrite; endoplasmic reticulum; growth cone; mitochondrion; neuronal cell body; nuclear body; nuclear membrane; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; postsynapse; protein-containing complex; ruffle
Molecular Function:  actin filament binding; actin monomer binding; ATP binding; bubble DNA binding; delta-catenin binding; DNA binding; ephrin receptor binding; four-way junction DNA binding; kinase activity; magnesium ion binding; manganese ion binding; mitogen-activated protein kinase binding; neuropilin binding; nicotinate-nucleotide adenylyltransferase activity; non-membrane spanning protein tyrosine kinase activity; phosphotyrosine residue binding; proline-rich region binding; protein binding; protein C-terminus binding; protein kinase activity; protein kinase C binding; protein self-association; protein tyrosine kinase activity; sequence-specific double-stranded DNA binding; SH2 domain binding; SH3 domain binding; supercoiled DNA binding; syntaxin binding; transcription coactivator activity
Biological Process:  actin cytoskeleton organization; actin filament polymerization; activated T cell proliferation; activation of protein kinase C activity; alpha-beta T cell differentiation; associative learning; autophagy; B cell proliferation involved in immune response; B cell receptor signaling pathway; B-1 B cell homeostasis; Bergmann glial cell differentiation; BMP signaling pathway; cardiac muscle cell proliferation; cell-cell adhesion; cellular response to DNA damage stimulus; cellular response to dopamine; cellular response to hydrogen peroxide; cellular response to lipopolysaccharide; cellular response to oxidative stress; cellular response to transforming growth factor beta stimulus; cellular senescence; cerebellum morphogenesis; DN4 thymocyte differentiation; DNA conformation change; endocytosis; endothelial cell migration; epidermal growth factor receptor signaling pathway; ERK1 and ERK2 cascade; establishment of localization in cell; Fc-gamma receptor signaling pathway involved in phagocytosis; I-kappaB kinase/NF-kappaB signaling; integrin-mediated signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage; microspike assembly; mismatch repair; mitochondrial depolarization; mitotic cell cycle; myoblast proliferation; negative regulation of BMP signaling pathway; negative regulation of cell-cell adhesion; negative regulation of cellular senescence; negative regulation of endothelial cell apoptotic process; negative regulation of ERK1 and ERK2 cascade; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of long-term synaptic potentiation; negative regulation of mitotic cell cycle; negative regulation of phospholipase C activity; negative regulation of protein serine/threonine kinase activity; negative regulation of ubiquitin-protein transferase activity; neural tube closure; neuroepithelial cell differentiation; neuromuscular process controlling balance; neuron death; neuron differentiation; neuropilin signaling pathway; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; platelet-derived growth factor receptor-beta signaling pathway; podocyte apoptotic process; positive regulation of actin cytoskeleton reorganization; positive regulation of actin filament binding; positive regulation of apoptotic process; positive regulation of blood vessel branching; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cytosolic calcium ion concentration; positive regulation of dendrite development; positive regulation of endothelial cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of establishment of T cell polarity; positive regulation of extracellular matrix organization; positive regulation of fibroblast proliferation; positive regulation of focal adhesion assembly; positive regulation of hydrogen peroxide-mediated programmed cell death; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-2 production; positive regulation of microtubule binding; positive regulation of mitotic cell cycle; positive regulation of neuron apoptotic process; positive regulation of osteoblast proliferation; positive regulation of oxidoreductase activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein phosphorylation; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of stress fiber assembly; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of T cell migration; positive regulation of transcription by RNA polymerase II; positive regulation of type II interferon production; positive regulation of vasoconstriction; positive regulation of Wnt signaling pathway, planar cell polarity pathway; post-embryonic development; protein autophosphorylation; protein localization to cytoplasmic microtubule plus-end; protein modification process; protein phosphorylation; regulation of actin cytoskeleton organization; regulation of actin cytoskeleton reorganization; regulation of apoptotic process; regulation of autophagy; regulation of axon extension; regulation of Cdc42 protein signal transduction; regulation of cell adhesion; regulation of cell cycle; regulation of cell motility; regulation of DNA-templated transcription; regulation of endocytosis; regulation of hematopoietic stem cell differentiation; regulation of microtubule polymerization; regulation of modification of synaptic structure; regulation of response to DNA damage stimulus; regulation of T cell differentiation; response to endoplasmic reticulum stress; response to epinephrine; response to oxidative stress; response to xenobiotic stimulus; signal transduction in response to DNA damage; spleen development; substrate adhesion-dependent cell spreading; T cell receptor signaling pathway; thymus development; transitional one stage B cell differentiation
Disease: Leukemia, Chronic Myeloid
Reference #:  P00519 (UniProtKB)
Alt. Names/Synonyms: Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; ABL; ABL proto-oncogene 1, non-receptor tyrosine kinase; ABL protooncogene 1 nonreceptor tyrosine kinase; ABL1; BCR-ABL; bcr/abl; bcr/c-abl oncogene protein; c-ABL; c-abl oncogene 1, receptor tyrosine kinase; c-ABL1; CHDSKM; JTK7; p150; Proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; truncated ABL protooncogene 1 nonreceptor tyrosine kinase; Tyrosine-protein kinase ABL1; v-abl; v-abl Abelson murine leukemia viral oncogene homolog 1
Gene Symbols: ABL1
Molecular weight: 122,873 Da
Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  G1/S Checkpoint  |  G2/M DNA Damage Checkpoint  |  Microtubule Dynamics  |  SAPK/JNK Signaling Cascades  |  TGF-ß Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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