53BP2 Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. Belongs to the ASPP family. Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte. Reduced expression in breast carcinomas expressing a wild-type TP53 protein. Overexpressed in lung cancer cell lines. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 1q41
Cellular Component:  cell junction; cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus; perinuclear region of cytoplasm
Molecular Function:  identical protein binding; NF-kappaB binding; p53 binding; protein binding; SH3 domain binding; SH3/SH2 adaptor activity
Biological Process:  cell cycle; intrinsic apoptotic signaling pathway by p53 class mediator; negative regulation of cell cycle; positive regulation of execution phase of apoptosis; positive regulation of neuron death; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; regulation of apoptotic process; regulation of signal transduction by p53 class mediator; signal transduction
Reference #:  Q13625 (UniProtKB)
Alt. Names/Synonyms: 53BP2; 53BP2S; Apoptosis-stimulating of p53 protein 2; apoptosis-stimulating protein of p53, 2; ASPP2; BBP; Bcl2-binding protein; NY-REN-51 antigen; p53-binding protein 2; p53BP2; PPP1R13A; Renal carcinoma antigen NY-REN-51; TP53BP2; tumor protein p53 binding protein, 2; Tumor suppressor p53-binding protein 2
Gene Symbols: TP53BP2
Molecular weight: 125,616 Da
Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene