CDC6 Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. Belongs to the CDC6/cdc18 family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 11|11 D
Cellular Component:  cytoplasm; nucleus; spindle; spindle midzone; spindle pole
Molecular Function:  ATP binding; chromatin binding; DNA replication origin binding; kinase binding; nucleotide binding
Biological Process:  cell cycle; cell division; DNA replication; DNA replication initiation; mitotic cell cycle; mitotic DNA replication checkpoint; positive regulation of chromosome segregation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of cytokinesis; positive regulation of fibroblast proliferation; regulation of mitotic metaphase/anaphase transition
Reference #:  O89033 (UniProtKB)
Alt. Names/Synonyms: CDC18; CDC18(S.pombe); CDC18L; Cdc6; CDC6-related protein; Cell division control protein 6 homolog; cell division cycle 18 homolog-like; cell division cycle 6; cell division cycle 6 homolog; cell division cycle 6 homolog (S. cerevisiae); OTTMUSP00000006852; OTTMUSP00000006853; p62(cdc6)
Gene Symbols: Cdc6
Molecular weight: 62,614 Da
Basal Isoelectric point: 9.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CDC6

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene