ELMO2 Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. Widely expressed, with a higher expression in skeletal muscle, kidney and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 20q13.12
Cellular Component:  cytosol; membrane
Molecular Function:  protein binding; receptor tyrosine kinase binding; SH3 domain binding
Biological Process:  actin filament organization; apoptotic process; cell chemotaxis; cell motility; cell-cell adhesion; phagocytosis
Disease: Vascular Malformation, Primary Intraosseous
Reference #:  Q96JJ3 (UniProtKB)
Alt. Names/Synonyms: CED-12; ced-12 homolog 2; Ced-12A; CED12; CED12A; ELMO-2; ELMO2; engulfment and cell motility 2; Engulfment and cell motility protein 2; FLJ11656; hCed-12A; KIAA1834; PH domain protein CED12A; Protein ced-12 homolog A; VMPI
Gene Symbols: ELMO2
Molecular weight: 82,615 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein