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ELMO2
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. Widely expressed, with a higher expression in skeletal muscle, kidney and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 20q13.12 |
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Cellular Component:
cytosol; membrane
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Molecular Function:
protein binding; receptor tyrosine kinase binding; SH3 domain binding
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Biological Process:
actin filament organization; apoptotic process; cell chemotaxis; cell motility; phagocytosis
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Disease: Vascular Malformation, Primary Intraosseous
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Reference #:
Q96JJ3
(UniProtKB)
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Alt. Names/Synonyms: CED-12; ced-12 homolog 2; Ced-12A; CED12; CED12A; ELMO-2; ELMO2; engulfment and cell motility 2; Engulfment and cell motility protein 2; FLJ11656; hCed-12A; KIAA1834; PH domain protein CED12A; Protein ced-12 homolog A; VMPI
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Gene Symbols: ELMO2
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Molecular weight:
82,615 Da
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Basal Isoelectric point:
5.62
Predict pI for various phosphorylation states
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