CDC6 Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. Belongs to the CDC6/cdc18 family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus; spindle midzone; spindle pole
Molecular Function:  ATP binding; kinase binding; nucleotide binding; protein binding
Biological Process:  cell division; cellular response to angiotensin; cellular response to vasopressin; DNA replication; DNA replication checkpoint; DNA replication initiation; G1/S transition of mitotic cell cycle; mitotic cell cycle; negative regulation of cell proliferation; negative regulation of DNA replication; positive regulation of chromosome segregation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of cytokinesis; positive regulation of fibroblast proliferation; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of mitotic metaphase/anaphase transition; regulation of transcription involved in G1/S transition of mitotic cell cycle; traversing start control point of mitotic cell cycle
Disease: Meier-gorlin Syndrome 5
Reference #:  Q99741 (UniProtKB)
Alt. Names/Synonyms: CDC18 (cell division cycle 18, S.pombe, homolog)-like; Cdc18-related protein; CDC18L; CDC6; CDC6 cell division cycle 6 homolog; CDC6-related protein; Cell division control protein 6 homolog; cell division cycle 6; cell division cycle 6 homolog; cell division cycle 6 homolog (S. cerevisiae); cell division cycle 6 protein; HsCdc18; HsCDC6; MGORS5; p62(cdc6)
Gene Symbols: CDC6
Molecular weight: 62,720 Da
Basal Isoelectric point: 9.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CDC6

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene