PIK3R3 Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. Belongs to the PI3K p85 subunit family. Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Kinase, lipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1p34.1
Cellular Component:  cytosol
Molecular Function:  1-phosphatidylinositol-3-kinase activity; phosphotyrosine residue binding; protein binding
Biological Process:  cell migration involved in sprouting angiogenesis; phosphatidylinositol biosynthetic process; phosphatidylinositol-3-phosphate biosynthetic process; positive regulation of cell migration; positive regulation of gene expression; positive regulation of protein phosphorylation; protein kinase B signaling
Reference #:  Q92569 (UniProtKB)
Alt. Names/Synonyms: 100% homology to SWISS-PROT Q92569; DKFZp686P05226; FLJ41892; p55; p55-GAMMA; P55G; p55PIK; Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; Phosphatidylinositol 3-kinase regulatory subunit gamma; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 3 (p55, gamma); phosphoinositide-3-kinase, regulatory subunit 3 (gamma); phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma); phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma); PI3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3K regulatory subunit gamma; PIK3R3; PtdIns-3-kinase regulatory subunit gamma; PtdIns-3-kinase regulatory subunit p55-gamma
Gene Symbols: PIK3R3
Molecular weight: 54,448 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein