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endophilin A2
Implicated in endocytosis. May recruit other proteins to membranes with high curvature. Belongs to the endophilin family. Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Oncoprotein; Vesicle |
| Chromosomal Location of human Ortholog: 19p13.3 |
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Cellular Component:
anchoring junction; cell projection; cytoplasm; cytosol; early endosome membrane; glutamatergic synapse; podosome; presynapse
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Molecular Function:
identical protein binding; lipid binding; protein binding
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Biological Process:
central nervous system development; signal transduction; synaptic vesicle uncoating
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Disease: Leukemia, Acute Myeloid
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Reference #:
Q99961
(UniProtKB)
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Alt. Names/Synonyms: CNSA1; EEN; EEN fusion partner of MLL; endophilin A2; Endophilin-2; Endophilin-A2; extra 11-19 leukemia fusion; Extra eleven-nineteen leukemia fusion gene protein; fusion partner of MLL; MGC111371; SH3 domain containing GRB2 like 1, endophilin A2; SH3 domain GRB2-like 1; SH3 domain protein 2B; SH3 domain-containing GRB2-like protein 1; SH3-containing Grb-2-like 1 protein; SH3-containing protein EEN; SH3-domain GRB2-like 1; SH3D2B; SH3G1; SH3GL1; SH3P8
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Gene Symbols: SH3GL1
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Molecular weight:
41,490 Da
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Basal Isoelectric point:
5.31
Predict pI for various phosphorylation states
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