CNR2 Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 4|4 D3
Cellular Component:  cell projection; dendrite; extrinsic component of cytoplasmic side of plasma membrane; integral component of membrane; membrane; neuron projection; neuronal cell body; plasma membrane
Molecular Function:  cannabinoid receptor activity; G protein-coupled receptor activity
Biological Process:  G protein-coupled receptor signaling pathway; inflammatory response; leukocyte chemotaxis; negative regulation of action potential; negative regulation of inflammatory response; negative regulation of mast cell activation; negative regulation of nitric-oxide synthase activity; negative regulation of synaptic transmission, GABAergic; response to lipopolysaccharide; sensory perception of pain; signal transduction
Reference #:  P47936 (UniProtKB)
Alt. Names/Synonyms: Cannabinoid receptor 2; cannabinoid receptor 2 (macrophage); cannabinoid receptor 2 (spleen); CB-2; CB2; CB2-R; Cnr2; mCB2; OTTMUSP00000010409; OTTMUSP00000010410
Gene Symbols: Cnr2
Molecular weight: 38,213 Da
Basal Isoelectric point: 8.38  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene