CNR2 Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. Belongs to the G-protein coupled receptor 1 family. Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 4|4 D3
Cellular Component:  cell projection; dendrite; extrinsic component of cytoplasmic side of plasma membrane; integral component of membrane; membrane; neuron projection; neuronal cell body; plasma membrane
Molecular Function:  cannabinoid receptor activity; G protein-coupled receptor activity
Biological Process:  G protein-coupled receptor signaling pathway; inflammatory response; leukocyte chemotaxis; negative regulation of action potential; negative regulation of inflammatory response; negative regulation of mast cell activation; negative regulation of nitric-oxide synthase activity; negative regulation of synaptic transmission, GABAergic; response to lipopolysaccharide; sensory perception of pain; signal transduction
Reference #:  P47936 (UniProtKB)
Alt. Names/Synonyms: Cannabinoid receptor 2; cannabinoid receptor 2 (macrophage); cannabinoid receptor 2 (spleen); CB-2; CB2; CB2-; CB2-R; Cnr2; mCB2; OTTMUSP00000010409; OTTMUSP00000010410
Gene Symbols: Cnr2
Molecular weight: 38,213 Da
Basal Isoelectric point: 8.38  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene