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TP2
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. Belongs to the nuclear transition protein 2 family. Expressed by spermatids (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding |
| Chromosomal Location of human Ortholog: 16p13.13 |
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Cellular Component:
nucleolus; nucleosome
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Molecular Function:
DNA binding; protein binding; zinc ion binding
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Biological Process:
acrosome reaction; penetration of zona pellucida; positive regulation of protein processing; sperm DNA condensation; spermatogenesis
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Reference #:
Q05952
(UniProtKB)
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Alt. Names/Synonyms: MGC116783; MGC116785; Nuclear transition protein 2; STP2; TNP2; TP-2; TP2; transition protein 2; transition protein 2 (during histone to protamine replacement)
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Gene Symbols: TNP2
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Molecular weight:
15,641 Da
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Basal Isoelectric point:
11.59
Predict pI for various phosphorylation states
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