TP2 Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. Belongs to the nuclear transition protein 2 family. Expressed by spermatids (at protein level). Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of rat Ortholog: 10q11
Cellular Component:  male germ cell nucleus; nucleolus; nucleosome; nucleus
Molecular Function:  DNA binding; metal ion binding; zinc ion binding
Biological Process:  acrosome reaction; binding of sperm to zona pellucida; flagellated sperm motility; penetration of zona pellucida; positive regulation of protein processing; sperm DNA condensation; spermatogenesis
Reference #:  P11101 (UniProtKB)
Alt. Names/Synonyms: haploid expressed, male germcell specific, chromatin binding; Nuclear transition protein 2; STP2; Tnp2; TP-2; TP2; transition protein 2
Gene Symbols: Tnp2
Molecular weight: 12,848 Da
Basal Isoelectric point: 11.8  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene