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TP2
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. Belongs to the nuclear transition protein 2 family. Expressed by spermatids (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding |
| Chromosomal Location of rat Ortholog: 10q11 |
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Cellular Component:
nuclear nucleosome; nucleolus; nucleus
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Molecular Function:
DNA binding; metal ion binding; zinc ion binding
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Biological Process:
acrosome reaction; binding of sperm to zona pellucida; flagellated sperm motility; multicellular organism development; penetration of zona pellucida; positive regulation of protein processing; spermatogenesis; spermatogenesis, exchange of chromosomal proteins
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Reference #:
P11101
(UniProtKB)
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Alt. Names/Synonyms: haploid expressed, male germcell specific, chromatin binding; Nuclear transition protein 2; STP2; Tnp2; TP-2; TP2; transition protein 2
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Gene Symbols: Tnp2
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Molecular weight:
12,848 Da
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Basal Isoelectric point:
11.8
Predict pI for various phosphorylation states
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