NHE3
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
Chromosomal Location of rat Ortholog: 1p11 |
Cellular Component:
apical plasma membrane; brush border; brush border membrane; early endosome; early endosome membrane; extracellular exosome; plasma membrane; recycling endosome membrane; vesicle
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Molecular Function:
identical protein binding; PDZ domain binding; phosphatidylinositol binding; potassium:proton antiporter activity; protein binding; sodium:proton antiporter activity
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Biological Process:
circadian rhythm; potassium ion transmembrane transport; proton transmembrane transport; receptor-mediated endocytosis; regulation of intracellular pH; regulation of pH; regulation of sodium ion transport; response to glucocorticoid; sodium ion import across plasma membrane; sodium ion transmembrane transport; sodium ion transport
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Reference #:
P26433
(UniProtKB)
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Alt. Names/Synonyms: Na(+)/H(+) exchanger 3; NHE-3; Nhe3; plasma membrane ion transport protein; SL9A3; Slc9a3; Sodium/hydrogen exchanger 3; Solute carrier family 9 (sodium/hydrogen exchanger 3), antiporter 3, Na+/H+ (amiloride insensitive); solute carrier family 9 (sodium/hydrogen exchanger), member 3; Solute carrier family 9 member 3; solute carrier family 9, member 3
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Gene Symbols: Slc9a3
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Molecular weight:
93,133 Da
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Basal Isoelectric point:
8.06
Predict pI for various phosphorylation states
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