CTLA-4 Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Immunoglobulin superfamily; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1 C2|1 30.58 cM
Cellular Component:  clathrin-coated endocytic vesicle; external side of plasma membrane; Golgi apparatus; integral component of membrane; integral component of plasma membrane; membrane; perinuclear region of cytoplasm; plasma membrane; protein complex involved in cell adhesion
Biological Process:  adaptive immune response; B cell receptor signaling pathway; cellular response to DNA damage stimulus; immune response; immune system process; negative regulation of B cell proliferation; negative regulation of immune response; negative regulation of regulatory T cell differentiation; negative regulation of T cell proliferation; positive regulation of apoptotic process; regulation of T cell proliferation; T cell receptor signaling pathway
Reference #:  P09793 (UniProtKB)
Alt. Names/Synonyms: Cd152; CD152 antigen; CTLA-4; Ctla4; Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated protein 4; Ly-56; OTTMUSP00000002168
Gene Symbols: Ctla4
Molecular weight: 24,993 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene