CTNNB1 a regulator of cell adhesion and a key downstream effector in the Wnt signaling pathway. Implicated early embryonic development and tumorigenesis. Phosphorylated and destabilized by CK1 and GSK-3beta. Stabilized cytoplasmic beta-catenin is a hallmark of a variety of cancers. Stabilized beta-catenin translocates to the nucleus, where it acts as a transcriptional activator of T-cell factor (TCF)-regulated genes. Interacts with the PDZ domain of TAX1BP3, inhibiting its transcriptional activity. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 9 F4|9 72.19 cM
Cellular Component:  adherens junction; apical junction complex; apical part of cell; basolateral plasma membrane; beta-catenin destruction complex; beta-catenin-TCF complex; beta-catenin-TCF7L2 complex; bicellular tight junction; catenin complex; cell cortex; cell junction; cell periphery; cell projection; cell projection membrane; cell-cell adherens junction; cell-cell junction; centrosome; cytoplasm; cytoskeleton; cytosol; dendritic shaft; fascia adherens; flotillin complex; intercalated disc; lamellipodium; lateral plasma membrane; membrane; microvillus membrane; nuclear euchromatin; nuclear membrane; nuclear transcription factor complex; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density, intracellular component; postsynaptic membrane; presynaptic active zone cytoplasmic component; presynaptic membrane; protein-containing complex; protein-DNA complex; Schaffer collateral - CA1 synapse; Scrib-APC-beta-catenin complex; synapse; transcription factor complex; Wnt signalosome; Z disc
Molecular Function:  alpha-catenin binding; cadherin binding; chromatin binding; disordered domain specific binding; DNA-binding transcription factor activity; enzyme binding; estrogen receptor binding; histone methyltransferase binding; I-SMAD binding; ion channel binding; ionotropic glutamate receptor binding; kinase binding; nitric-oxide synthase binding; nuclear hormone receptor binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein kinase binding; protein phosphatase binding; protein-containing complex binding; repressing transcription factor binding; RNA polymerase II activating transcription factor binding; RNA polymerase II transcription factor binding; SMAD binding; transcription coactivator activity; transcription factor binding
Biological Process:  adherens junction assembly; adherens junction organization; animal organ development; anterior/posterior axis specification; bone resorption; branching involved in blood vessel morphogenesis; branching involved in ureteric bud morphogenesis; canonical Wnt signaling pathway; canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition; cardiac muscle cell proliferation; cardiac vascular smooth muscle cell differentiation; cell adhesion; cell differentiation; cell fate determination; cell fate specification; cell maturation; cell morphogenesis involved in differentiation; cell proliferation; cell-cell adhesion; cell-matrix adhesion; cellular process; cellular protein localization; cellular response to growth factor stimulus; cellular response to indole-3-methanol; cellular response to insulin-like growth factor stimulus; cellular response to mechanical stimulus; central nervous system vasculogenesis; chemical synaptic transmission; chromatin-mediated maintenance of transcription; coronary artery morphogenesis; cranial ganglion development; cranial skeletal system development; dorsal root ganglion development; dorsal/ventral axis specification; dorsal/ventral pattern formation; ectoderm development; embryonic axis specification; embryonic brain development; embryonic digit morphogenesis; embryonic foregut morphogenesis; embryonic forelimb morphogenesis; embryonic heart tube development; embryonic hindlimb morphogenesis; embryonic skeletal limb joint morphogenesis; endoderm formation; endodermal cell fate commitment; endothelial tube morphogenesis; epicardium-derived cardiac vascular smooth muscle cell differentiation; epithelial cell differentiation involved in prostate gland development; epithelial tube branching involved in lung morphogenesis; forebrain development; fungiform papilla formation; gastrulation with mouth forming second; genitalia morphogenesis; glial cell fate determination; hair cycle process; hair follicle morphogenesis; hair follicle placode formation; heart development; hemopoiesis; hindbrain development; in utero embryonic development; kidney development; layer formation in cerebral cortex; lens morphogenesis in camera-type eye; limb development; lung cell differentiation; lung development; lung induction; lung-associated mesenchyme development; male genitalia development; mesenchymal cell proliferation involved in lung development; mesenchyme development; mesenchyme morphogenesis; metanephros morphogenesis; midbrain development; midbrain dopaminergic neuron differentiation; morphogenesis of embryonic epithelium; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of apoptotic signaling pathway; negative regulation of cell differentiation; negative regulation of cell proliferation; negative regulation of chondrocyte differentiation; negative regulation of gene expression; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; negative regulation of mitotic cell cycle, embryonic; negative regulation of neurogenesis; negative regulation of neuron death; negative regulation of oligodendrocyte differentiation; negative regulation of osteoclast differentiation; negative regulation of oxidative stress-induced neuron death; negative regulation of protein sumoylation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; nephron tubule formation; nervous system development; neural plate development; neuron differentiation; neuron migration; neuron projection extension; odontogenesis of dentin-containing tooth; oocyte development; osteoclast differentiation; oviduct development; pancreas development; positive regulation of apoptotic process; positive regulation of branching involved in lung morphogenesis; positive regulation of cell proliferation; positive regulation of chromatin-mediated maintenance of transcription; positive regulation of core promoter binding; positive regulation of determination of dorsal identity; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription, initiation; positive regulation of endothelial cell differentiation; positive regulation of epithelial cell differentiation; positive regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of epithelial to mesenchymal transition; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of gene expression; positive regulation of heparan sulfate proteoglycan biosynthetic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of MAPK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of molecular function; positive regulation of neural precursor cell proliferation; positive regulation of neuroblast proliferation; positive regulation of neuron apoptotic process; positive regulation of osteoblast differentiation; positive regulation of skeletal muscle tissue development; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; proteasome-mediated ubiquitin-dependent protein catabolic process; protein heterooligomerization; protein localization to cell surface; protein polyubiquitination; proximal/distal pattern formation; regulation of apoptotic process; regulation of calcium ion import; regulation of cell differentiation; regulation of cell proliferation; regulation of centriole-centriole cohesion; regulation of centromeric sister chromatid cohesion; regulation of chromatin-mediated maintenance of transcription; regulation of core promoter binding; regulation of epithelial cell differentiation; regulation of euchromatin binding; regulation of gene expression; regulation of histone demethylase activity (H3-K4 specific); regulation of histone H3-K4 methylation; regulation of myelination; regulation of nephron tubule epithelial cell differentiation; regulation of osteoblast differentiation; regulation of osteoclast differentiation; regulation of protein localization to cell surface; regulation of secondary heart field cardioblast proliferation; regulation of smooth muscle cell proliferation; regulation of T cell proliferation; regulation of timing of anagen; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; renal inner medulla development; renal outer medulla development; renal vesicle formation; response to cytokine; response to estradiol; response to estrogen; Schwann cell proliferation; skeletal system development; skin development; smooth muscle cell differentiation; stem cell population maintenance; sympathetic ganglion development; synapse organization; synaptic vesicle clustering; synaptic vesicle transport; T cell differentiation; T cell differentiation in thymus; thymus development; tissue homeostasis; trachea formation; trachea morphogenesis; vasculature development; vasculogenesis; ventricular compact myocardium morphogenesis; Wnt signaling pathway
Reference #:  Q02248 (UniProtKB)
Alt. Names/Synonyms: Beta-catenin; catenin (cadherin associated protein), beta 1; Catenin beta-1; Catnb; CTNB1; Ctnnb1; Mesc; OTTMUSP00000017750
Gene Symbols: Ctnnb1
Molecular weight: 85,471 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CTNNB1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA