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EPS15
Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Oncoprotein; Vesicle |
| Chromosomal Location of human Ortholog: 1p32.3 |
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Cellular Component:
aggresome; apical plasma membrane; basal plasma membrane; clathrin coat of coated pit; clathrin-coated pit; cytoplasm; cytosol; early endosome membrane; glutamatergic synapse; intracellular membrane-bounded organelle; plasma membrane; postsynapse
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Molecular Function:
calcium ion binding; polyubiquitin modification-dependent protein binding; protein binding; SH3 domain binding
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Biological Process:
clathrin coat assembly; endocytic recycling; endocytosis; endosomal transport; Golgi to endosome transport; positive regulation of receptor recycling; postsynaptic neurotransmitter receptor internalization; protein transport; receptor-mediated endocytosis of virus by host cell; regulation of cell population proliferation; vesicle organization; viral entry into host cell
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Reference #:
P42566
(UniProtKB)
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Alt. Names/Synonyms: AF-1P; AF1P; ALL1 fused gene from chromosome 1; epidermal growth factor receptor pathway substrate 15; Epidermal growth factor receptor substrate 15; EPS15; MLLT5; Protein AF-1p; Protein Eps15
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Gene Symbols: EPS15
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Molecular weight:
98,656 Da
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Basal Isoelectric point:
4.52
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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