FXR1 RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs. Belongs to the FMR1 family. Expressed in all tissues examined including heart, brain, kidney and testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Translation
Chromosomal Location of Human Ortholog: 3q26.33
Cellular Component:  costamere; cytosol; glutamatergic synapse; nucleolus; perinuclear region of cytoplasm
Molecular Function:  protein binding; protein heterodimerization activity; protein homodimerization activity; RNA strand annealing activity
Biological Process:  apoptotic process; cell differentiation; muscle organ development; positive regulation of gene silencing by miRNA
Disease: Myopathy, Congenital Proximal, With Minicore Lesions; Myopathy, Congenital, With Respiratory Insufficiency And Bone Fractures
Reference #:  P51114 (UniProtKB)
Alt. Names/Synonyms: Fragile X mental retardation syndrome-related protein 1; fragile X mental retardation, autosomal homolog 1; FXR1; hFXR1p
Gene Symbols: FXR1
Molecular weight: 69,721 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein