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nectin 2
Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein. (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). Belongs to the nectin family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Membrane protein, integral |
| Chromosomal Location of mouse Ortholog: 7 A3|7 9.94 cM |
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Cellular Component:
apical junction complex; cell surface; cell-cell contact zone; cell-cell junction; membrane; plasma membrane; zonula adherens
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Molecular Function:
cell adhesion molecule binding; identical protein binding; protein binding; protein homodimerization activity
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Biological Process:
acrosome assembly; adhesion of symbiont to host; cell adhesion; cell part morphogenesis; cilium organization; coreceptor-mediated virion attachment to host cell; cytoskeleton organization; establishment of localization in cell; establishment of mitochondrion localization; fertilization; fusion of virus membrane with host plasma membrane; homophilic cell adhesion via plasma membrane adhesion molecules; positive regulation of immunoglobulin mediated immune response; positive regulation of mast cell activation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of T cell receptor signaling pathway; regulation of viral entry into host cell; sperm mitochondrion organization; spermatid development; spermatid nucleus differentiation; susceptibility to natural killer cell mediated cytotoxicity; susceptibility to T cell mediated cytotoxicity
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Reference #:
P32507
(UniProtKB)
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Alt. Names/Synonyms: AI325026; AI987993; Cd112; Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; mHveB; Mph; Murine herpes virus entry protein B; murine herpesvirus entry protein B; NECT2; necti; nectin 2; Nectin cell adhesion molecule 2; Nectin-2; Nectin2; Poliovirus receptor homolog; poliovirus receptor-related 2; Poliovirus receptor-related protein 2; poliovirus sensitivity; Pvr; Pvrl2; Pvs
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Gene Symbols: Nectin2
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Molecular weight:
57,318 Da
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Basal Isoelectric point:
4.77
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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