G3BP-2 Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; RNA-binding
Chromosomal Location of Human Ortholog: 4q21.1
Cellular Component:  cytoplasm; cytoplasmic stress granule; cytosol
Molecular Function:  protein binding; receptor signaling complex scaffold activity
Biological Process:  cytoplasmic sequestering of NF-kappaB; mRNA transport; positive regulation of signal transduction; positive regulation of stress granule assembly; protein homooligomerization; Ras protein signal transduction; stress granule assembly; viral process
Reference #:  Q9UN86 (UniProtKB)
Alt. Names/Synonyms: G3BP stress granule assembly factor 2; G3BP-2; G3BP2; GAP SH3 domain-binding protein 2; GTPase activating protein (SH3 domain) binding protein 2; KIAA0660; Ras GTPase-activating protein-binding protein 2; Ras-GTPase activating protein SH3 domain-binding protein 2
Gene Symbols: G3BP2
Molecular weight: 54,121 Da
Basal Isoelectric point: 5.41  Predict pI for various phosphorylation states
Select Structure to View Below

G3BP-2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein