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EIF3E
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins. Belongs to the eIF-3 subunit E family. Ubiquitously expressed. Expressed at highest levels in appendix, lymph, pancreas, skeletal muscle, spleen and thymus. Note: This description may include information from UniProtKB.
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| Protein type: Translation; Translation initiation |
| Chromosomal Location of human Ortholog: 8q23.1 |
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Cellular Component:
cytoplasm; cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; eukaryotic translation initiation factor 3 complex, eIF3e; nucleoplasm; nucleus; PML body; postsynaptic density
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Molecular Function:
protein binding; translation initiation factor activity
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Biological Process:
formation of cytoplasmic translation initiation complex; negative regulation of translational initiation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; positive regulation of mRNA binding; positive regulation of translation; regulation of translational initiation; translational initiation
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Reference #:
P60228
(UniProtKB)
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Alt. Names/Synonyms: eIF-3 p48; eIF3-p46; EIF3-P48; EIF3E; EIF3S6; Eukaryotic translation initiation factor 3 subunit 6; Eukaryotic translation initiation factor 3 subunit E; eukaryotic translation initiation factor 3, subunit 6 (48kD); eukaryotic translation initiation factor 3, subunit 6 48kDa; eukaryotic translation initiation factor 3, subunit E; INT6; mammary tumor-associated protein INT6; murine mammary tumor integration site 6 (oncogene homolog); Viral integration site protein INT-6 homolog
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Gene Symbols: EIF3E
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Molecular weight:
52,221 Da
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Basal Isoelectric point:
5.71
Predict pI for various phosphorylation states
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CST Pathways:
Translational Control
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