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H1R
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of Human Ortholog: 3p25.3 |
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Cellular Component:
cytosol; integral component of plasma membrane; plasma membrane
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Molecular Function:
histamine receptor activity
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Biological Process:
cellular response to histamine; eosinophil chemotaxis; G protein-coupled receptor signaling pathway; G protein-coupled serotonin receptor signaling pathway; inflammatory response; inositol phosphate-mediated signaling; memory; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of inositol trisphosphate biosynthetic process; positive regulation of vasoconstriction; regulation of synaptic plasticity; regulation of vascular permeability; visual learning
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Reference #:
P35367
(UniProtKB)
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Alt. Names/Synonyms: H1-R; H1R; HH1R; hisH1; histamine H(1) receptor; Histamine H1 receptor; histamine receptor H1; histamine receptor, subclass H1; HRH1
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Gene Symbols: HRH1
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Molecular weight:
55,784 Da
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Basal Isoelectric point:
9.33
Predict pI for various phosphorylation states
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