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PLD2
May have a role in signal-induced cytoskeletal regulation and/or endocytosis. Belongs to the phospholipase D family. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase |
| Chromosomal Location of Human Ortholog: 11 B3|11 42.99 cM |
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Cellular Component:
brush border membrane; caveola; Golgi apparatus; lamellipodium; membrane; nucleus; plasma membrane; sarcolemma
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Molecular Function:
catalytic activity; hydrolase activity; N-acylphosphatidylethanolamine-specific phospholipase D activity; phosphatidylinositol binding; phospholipase D activity; protein kinase C binding
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Biological Process:
cell motility; G protein-coupled receptor internalization; inositol lipid-mediated signaling; lipid catabolic process; lipid metabolic process; neuron projection development; phosphatidic acid biosynthetic process; phospholipid catabolic process; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of mast cell degranulation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of receptor-mediated endocytosis; receptor-mediated endocytosis; response to hydrogen peroxide; response to hypoxia; response to organic cyclic compound; response to peptide hormone
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Reference #:
P97813
(UniProtKB)
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Alt. Names/Synonyms: Choline phosphatase 2; mPLD2; OTTMUSP00000006320; Phosphatidylcholine-hydrolyzing phospholipase D2; Phospholipase D2; PLD 2; PLD1C; Pld2
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Gene Symbols: Pld2
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Molecular weight:
106,168 Da
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Basal Isoelectric point:
6.96
Predict pI for various phosphorylation states
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