PLD2 May have a role in signal-induced cytoskeletal regulation and/or endocytosis. Belongs to the phospholipase D family. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase
Chromosomal Location of mouse Ortholog: 11 B3|11 42.99 cM
Cellular Component:  brush border membrane; caveola; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; lamellipodium; membrane; plasma membrane; plasma membrane region; sarcolemma
Molecular Function:  catalytic activity; hydrolase activity; N-acylphosphatidylethanolamine-specific phospholipase D activity; phosphatidylinositol binding; phospholipase D activity; protein kinase C binding
Biological Process:  G protein-coupled receptor internalization; inositol lipid-mediated signaling; lipid catabolic process; lipid metabolic process; neuron projection development; phosphatidic acid biosynthetic process; phospholipid catabolic process; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of mast cell degranulation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of receptor-mediated endocytosis; receptor-mediated endocytosis; regulation of vesicle-mediated transport; response to hydrogen peroxide; response to hypoxia; response to organic cyclic compound; response to peptide hormone
Reference #:  P97813 (UniProtKB)
Alt. Names/Synonyms: Choline phosphatase 2; mPLD2; OTTMUSP00000006320; Phosphatidylcholine-hydrolyzing phospholipase D2; Phospholipase D2; PLD 2; PLD1C; Pld2
Gene Symbols: Pld2
Molecular weight: 106,168 Da
Basal Isoelectric point: 6.96  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene