CTNNB1 a regulator of cell adhesion and a key downstream effector in the Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Implicated early embryonic development and tumorigenesis. Phosphorylated and destabilized by CK1 and GSK-3beta. Stabilized cytoplasmic beta-catenin is a hallmark of a variety of cancers. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Stabilized beta-catenin translocates to the nucleus, where it acts as a transcriptional activator of T-cell factor (TCF)-regulated genes. Interacts with the PDZ domain of TAX1BP3, inhibiting its transcriptional activity. Has 1 described isoform and 17 potential isoforms that are computationally mapped. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 3p22.1
Cellular Component:  adherens junction; apical part of cell; basolateral plasma membrane; beta-catenin destruction complex; beta-catenin-TCF complex; beta-catenin-TCF7L2 complex; bicellular tight junction; catenin complex; cell cortex; cell junction; cell periphery; cell-cell adherens junction; cell-cell junction; centrosome; cytoplasm; cytosol; fascia adherens; flotillin complex; lamellipodium; lateral plasma membrane; membrane; microvillus membrane; nuclear euchromatin; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density, intracellular component; postsynaptic membrane; presynaptic active zone cytoplasmic component; presynaptic membrane; protein-containing complex; protein-DNA complex; Schaffer collateral - CA1 synapse; Scrib-APC-beta-catenin complex; spindle pole; synapse; transcription factor complex; Wnt signalosome; Z disc
Molecular Function:  alpha-catenin binding; androgen receptor binding; cadherin binding; chromatin binding; disordered domain specific binding; DNA-binding transcription factor activity; enzyme binding; estrogen receptor binding; I-SMAD binding; ion channel binding; kinase binding; nuclear hormone receptor binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein kinase binding; protein phosphatase binding; repressing transcription factor binding; RNA polymerase II activating transcription factor binding; RNA polymerase II transcription factor binding; SMAD binding; transcription coactivator activity; transcription factor binding
Biological Process:  adherens junction assembly; androgen receptor signaling pathway; anterior/posterior axis specification; beta-catenin destruction complex disassembly; beta-catenin-TCF complex assembly; bone resorption; branching involved in blood vessel morphogenesis; branching involved in ureteric bud morphogenesis; canonical Wnt signaling pathway; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; canonical Wnt signaling pathway involved in negative regulation of apoptotic process; canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition; cell adhesion; cell fate specification; cell maturation; cell morphogenesis involved in differentiation; cell-cell adhesion; cell-matrix adhesion; cellular response to growth factor stimulus; cellular response to indole-3-methanol; central nervous system vasculogenesis; chemical synaptic transmission; chromatin-mediated maintenance of transcription; cranial ganglion development; cranial skeletal system development; dorsal root ganglion development; dorsal/ventral axis specification; ectoderm development; embryonic axis specification; embryonic brain development; embryonic digit morphogenesis; embryonic foregut morphogenesis; embryonic forelimb morphogenesis; embryonic heart tube development; embryonic hindlimb morphogenesis; embryonic skeletal limb joint morphogenesis; endodermal cell fate commitment; endothelial tube morphogenesis; entry of bacterium into host cell; epithelial cell differentiation involved in prostate gland development; epithelial to mesenchymal transition; epithelial tube branching involved in lung morphogenesis; fungiform papilla formation; gastrulation with mouth forming second; genitalia morphogenesis; glial cell fate determination; hair cell differentiation; hair follicle morphogenesis; hair follicle placode formation; hindbrain development; in utero embryonic development; layer formation in cerebral cortex; lens morphogenesis in camera-type eye; lung cell differentiation; lung induction; lung-associated mesenchyme development; male genitalia development; mesenchymal cell proliferation involved in lung development; metanephros morphogenesis; midbrain dopaminergic neuron differentiation; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of apoptotic signaling pathway; negative regulation of cell proliferation; negative regulation of chondrocyte differentiation; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; negative regulation of mitotic cell cycle, embryonic; negative regulation of oligodendrocyte differentiation; negative regulation of osteoclast differentiation; negative regulation of oxidative stress-induced neuron death; negative regulation of protein sumoylation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; nephron tubule formation; neural plate development; neuron migration; neuron projection extension; odontogenesis of dentin-containing tooth; oocyte development; osteoclast differentiation; oviduct development; pancreas development; positive regulation of apoptotic process; positive regulation of chromatin-mediated maintenance of transcription; positive regulation of core promoter binding; positive regulation of determination of dorsal identity; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription, initiation; positive regulation of endothelial cell differentiation; positive regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of epithelial to mesenchymal transition; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of heparan sulfate proteoglycan biosynthetic process; positive regulation of histone H3-K4 methylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of MAPK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of muscle cell differentiation; positive regulation of neuroblast proliferation; positive regulation of neuron apoptotic process; positive regulation of osteoblast differentiation; positive regulation of skeletal muscle tissue development; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of type I interferon production; proteasome-mediated ubiquitin-dependent protein catabolic process; protein localization to cell surface; protein polyubiquitination; proximal/distal pattern formation; regulation of angiogenesis; regulation of calcium ion import; regulation of canonical Wnt signaling pathway; regulation of centriole-centriole cohesion; regulation of centromeric sister chromatid cohesion; regulation of euchromatin binding; regulation of fibroblast proliferation; regulation of myelination; regulation of nephron tubule epithelial cell differentiation; regulation of neurogenesis; regulation of protein localization to cell surface; regulation of secondary heart field cardioblast proliferation; regulation of smooth muscle cell proliferation; regulation of T cell proliferation; regulation of timing of anagen; renal inner medulla development; renal outer medulla development; renal vesicle formation; response to drug; response to estradiol; smooth muscle cell differentiation; stem cell population maintenance; sympathetic ganglion development; synapse organization; synaptic vesicle clustering; synaptic vesicle transport; T cell differentiation in thymus; thymus development; trachea formation; viral process; Wnt signaling pathway; Wnt signaling pathway, calcium modulating pathway
Disease: Colorectal Cancer; Exudative Vitreoretinopathy 7; Hepatocellular Carcinoma; Medulloblastoma; Mental Retardation, Autosomal Dominant 19; Ovarian Cancer; Pilomatrixoma
Reference #:  P35222 (UniProtKB)
Alt. Names/Synonyms: armadillo; Beta-catenin; catenin (cadherin-associated protein), beta 1, 88kDa; catenin beta 1; Catenin beta-1; CTNB1; CTNNB; CTNNB1; DKFZp686D02253; EVR7; FLJ25606; FLJ37923; MRD19; NEDSDV
Gene Symbols: CTNNB1
Molecular weight: 85,497 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein