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CTNNB1
a regulator of cell adhesion and a key downstream effector in the Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Implicated early embryonic development and tumorigenesis. Phosphorylated and destabilized by CK1 and GSK-3beta. Stabilized cytoplasmic beta-catenin is a hallmark of a variety of cancers. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Stabilized beta-catenin translocates to the nucleus, where it acts as a transcriptional activator of T-cell factor (TCF)-regulated genes. Interacts with the PDZ domain of TAX1BP3, inhibiting its transcriptional activity. Has 1 described isoform and 17 potential isoforms that are computationally mapped. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor |
| Chromosomal Location of human Ortholog: 3p22.1 |
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Cellular Component:
adherens junction; apical part of cell; apicolateral plasma membrane; basolateral plasma membrane; beta-catenin destruction complex; beta-catenin-ICAT complex; beta-catenin-TCF complex; beta-catenin-TCF7L2 complex; bicellular tight junction; catenin complex; cell cortex; cell junction; cell periphery; cell-cell junction; centrosome; cytoplasm; cytosol; euchromatin; fascia adherens; flotillin complex; glutamatergic synapse; lamellipodium; lateral plasma membrane; membrane; microvillus membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density, intracellular component; postsynaptic membrane; presynaptic active zone cytoplasmic component; presynaptic membrane; protein-containing complex; protein-DNA complex; Schaffer collateral - CA1 synapse; Scrib-APC-beta-catenin complex; spindle pole; synapse; transcription regulator complex; Wnt signalosome; Z disc
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Molecular Function:
alpha-catenin binding; cadherin binding; chromatin binding; disordered domain specific binding; DNA-binding transcription factor binding; enzyme binding; histone methyltransferase binding; I-SMAD binding; kinase binding; nuclear estrogen receptor binding; nuclear receptor binding; protein binding; protein kinase binding; protein phosphatase binding; RNA polymerase II-specific DNA-binding transcription factor binding; SMAD binding; transcription coactivator activity; transcription coregulator binding; transcription corepressor binding; transmembrane transporter binding; ubiquitin protein ligase binding
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Biological Process:
acinar cell differentiation; adherens junction assembly; anterior/posterior axis specification; apoptotic signaling pathway; astrocyte-dopaminergic neuron signaling; bone resorption; branching involved in blood vessel morphogenesis; branching involved in ureteric bud morphogenesis; canonical Wnt signaling pathway; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; canonical Wnt signaling pathway involved in negative regulation of apoptotic process; canonical Wnt signaling pathway involved in osteoblast differentiation; canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition; cell adhesion; cell fate specification; cell maturation; cell morphogenesis involved in differentiation; cell-cell adhesion; cell-matrix adhesion; cellular response to growth factor stimulus; cellular response to indole-3-methanol; central nervous system vasculogenesis; chemical synaptic transmission; chondrocyte differentiation; cranial ganglion development; cranial skeletal system development; detection of muscle stretch; dorsal root ganglion development; dorsal/ventral axis specification; ectoderm development; embryonic axis specification; embryonic brain development; embryonic digit morphogenesis; embryonic foregut morphogenesis; embryonic forelimb morphogenesis; embryonic heart tube development; embryonic hindlimb morphogenesis; embryonic skeletal limb joint morphogenesis; endodermal cell fate commitment; endothelial tube morphogenesis; epithelial cell differentiation involved in prostate gland development; epithelial cell proliferation involved in prostate gland development; epithelial to mesenchymal transition; epithelial tube branching involved in lung morphogenesis; establishment of blood-brain barrier; establishment of blood-retinal barrier; fibroblast growth factor receptor signaling pathway; fungiform papilla formation; gastrulation with mouth forming second; gene expression; genitalia morphogenesis; glial cell fate determination; hair cell differentiation; hair follicle morphogenesis; hair follicle placode formation; hindbrain development; hypothalamus development; I-kappaB kinase/NF-kappaB signaling; in utero embryonic development; layer formation in cerebral cortex; lens morphogenesis in camera-type eye; lung epithelial cell differentiation; lung induction; lung-associated mesenchyme development; male genitalia development; MAPK cascade; mesenchymal cell proliferation involved in lung development; mesenchymal stem cell differentiation; metanephros morphogenesis; midbrain dopaminergic neuron differentiation; myoblast proliferation; negative regulation of angiogenesis; negative regulation of apoptotic process; negative regulation of canonical Wnt signaling pathway; negative regulation of cell population proliferation; negative regulation of chondrocyte differentiation; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; negative regulation of mitotic cell cycle, embryonic; negative regulation of oligodendrocyte differentiation; negative regulation of osteoclast differentiation; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; negative regulation of protein sumoylation; negative regulation of transcription by RNA polymerase II; nephron tubule formation; neural plate development; neuroblast proliferation; neuron fate determination; neuron migration; neuron projection extension; odontogenesis of dentin-containing tooth; oligodendrocyte differentiation; oocyte development; osteoclast differentiation; oviduct development; pancreas development; positive regulation of apoptotic process; positive regulation of branching involved in lung morphogenesis; positive regulation of cell differentiation; positive regulation of core promoter binding; positive regulation of determination of dorsal identity; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of endothelial cell differentiation; positive regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of epithelial to mesenchymal transition; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of gene expression; positive regulation of heparan sulfate proteoglycan biosynthetic process; positive regulation of histone H3-K4 methylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of MAPK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of myoblast proliferation; positive regulation of neuroblast proliferation; positive regulation of neuron apoptotic process; positive regulation of osteoblast differentiation; positive regulation of skeletal muscle tissue development; positive regulation of stem cell proliferation; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; positive regulation of transcription by RNA polymerase II; positive regulation of transcription elongation by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein localization to cell surface; protein polyubiquitination; proximal/distal pattern formation; regulation of angiogenesis; regulation of calcium ion import; regulation of centriole-centriole cohesion; regulation of centromeric sister chromatid cohesion; regulation of fibroblast proliferation; regulation of myelination; regulation of nephron tubule epithelial cell differentiation; regulation of neurogenesis; regulation of protein localization to cell surface; regulation of protein ubiquitination; regulation of secondary heart field cardioblast proliferation; regulation of smooth muscle cell proliferation; regulation of synapse assembly; regulation of T cell proliferation; regulation of timing of anagen; renal inner medulla development; renal outer medulla development; renal vesicle formation; response to estradiol; response to xenobiotic stimulus; smooth muscle cell differentiation; stem cell population maintenance; stem cell proliferation; sympathetic ganglion development; synapse organization; synaptic vesicle clustering; synaptic vesicle transport; T cell differentiation in thymus; thymus development; trachea formation; transcription by RNA polymerase II
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Disease: Colorectal Cancer; Exudative Vitreoretinopathy 7; Hepatocellular Carcinoma; Medulloblastoma; Mental Retardation, Autosomal Dominant 19; Pilomatrixoma
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Reference #:
P35222
(UniProtKB)
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Alt. Names/Synonyms: armadillo; Beta-catenin; catenin (cadherin-associated protein), beta 1, 88kDa; catenin beta 1; Catenin beta-1; CTNB1; CTNNB; CTNNB1; DKFZp686D02253; EVR7; FLJ25606; FLJ37923; MRD19; NEDSDV
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Gene Symbols: CTNNB1
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Molecular weight:
85,497 Da
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Basal Isoelectric point:
5.53
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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ErbB/HER Signaling
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ESC Pluripotency and Differentiation
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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