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ACTN4
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA. Belongs to the alpha-actinin family. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 19q13.2 |
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Cellular Component:
actin cytoskeleton; cell junction; cell projection; cortical actin cytoskeleton; cytoplasm; extracellular region; nucleus; perinuclear region of cytoplasm; plasma membrane; platelet alpha granule lumen; protein-containing complex; pseudopodium; ribonucleoprotein complex; Z disc
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Molecular Function:
actin binding; actin filament binding; calcium ion binding; chromatin DNA binding; integrin binding; nuclear receptor binding; nuclear receptor coactivator activity; nuclear retinoic acid receptor binding; nucleoside binding; protein binding; protein homodimerization activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription coactivator activity; transmembrane transporter binding
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Biological Process:
actin cytoskeleton organization; muscle cell development; negative regulation of substrate adhesion-dependent cell spreading; peroxisome proliferator activated receptor signaling pathway; positive regulation of cell migration; positive regulation of NIK/NF-kappaB signaling; positive regulation of sodium:proton antiporter activity; positive regulation of transcription by RNA polymerase II; protein transport; regulation of apoptotic process; retinoic acid receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; vesicle transport along actin filament
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Disease: Focal Segmental Glomerulosclerosis 1
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Reference #:
O43707
(UniProtKB)
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Alt. Names/Synonyms: actinin alpha 4; actinin alpha4 isoform; actinin, alpha 4; ACTININ-4; ACTN4; Alpha-actinin-4; DKFZp686K23158; focal segmental glomerulosclerosis 1; FSGS; FSGS1; Non-muscle alpha-actinin 4
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Gene Symbols: ACTN4
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Molecular weight:
104,854 Da
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Basal Isoelectric point:
5.27
Predict pI for various phosphorylation states
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CST Pathways:
T Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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