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COMT
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. Brain, liver, placenta, lymphocytes and erythrocytes. 2 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - tyrosine; EC 2.1.1.6; Membrane protein, integral; Methyltransferase |
| Chromosomal Location of Human Ortholog: 22q11.21 |
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Cellular Component:
cell body; cytosol; dendritic spine; integral component of membrane; intracellular membrane-bounded organelle; plasma membrane; postsynaptic membrane
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Molecular Function:
catechol O-methyltransferase activity; L-dopa O-methyltransferase activity; magnesium ion binding; methyltransferase activity; O-methyltransferase activity; orcinol O-methyltransferase activity; protein binding
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Biological Process:
catecholamine catabolic process; cellular response to phosphate starvation; dopamine catabolic process; estrogen metabolic process; female pregnancy; learning; methylation; multicellular organismal reproductive process; negative regulation of dopamine metabolic process; negative regulation of renal sodium excretion; negative regulation of smooth muscle cell proliferation; neurotransmitter catabolic process; positive regulation of homocysteine metabolic process; regulation of sensory perception of pain; response to drug; response to estrogen; response to lipopolysaccharide; response to organic cyclic compound; response to pain; short-term memory
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Disease: Panic Disorder 1; Schizophrenia
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Reference #:
P21964
(UniProtKB)
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Alt. Names/Synonyms: Catechol O-methyltransferase; catechol-O-methyltransferase; COMT
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Gene Symbols: COMT
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Molecular weight:
30,037 Da
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Basal Isoelectric point:
5.26
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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