COMT Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. Brain, liver, placenta, lymphocytes and erythrocytes. 2 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tyrosine; EC; Membrane protein, integral; Methyltransferase
Chromosomal Location of human Ortholog: 22q11.21
Cellular Component:  axon; cytosol; dendrite; intracellular membrane-bounded organelle; membrane; plasma membrane
Molecular Function:  catechol O-methyltransferase activity; L-dopa O-methyltransferase activity; magnesium ion binding; methyltransferase activity; O-methyltransferase activity; orcinol O-methyltransferase activity; protein binding
Biological Process:  catecholamine catabolic process; cellular response to phosphate starvation; developmental process; dopamine catabolic process; dopamine metabolic process; lipid metabolic process; methylation; neurotransmitter catabolic process
Disease: Panic Disorder 1; Schizophrenia
Reference #:  P21964 (UniProtKB)
Alt. Names/Synonyms: Catechol O-methyltransferase; catechol-O-methyltransferase; COMT; epididymis secretory sperm binding protein Li 98n; HEL-S-98n; testicular tissue protein Li 42
Gene Symbols: COMT
Molecular weight: 30,037 Da
Basal Isoelectric point: 5.26  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein