SWAP-70 Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion. Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760). Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho
Chromosomal Location of Human Ortholog: 11p15.4
Cellular Component:  cytoplasm; cytoskeleton; lamellipodium; plasma membrane
Molecular Function:  ATP binding; calcium ion binding; DNA binding; protein binding
Biological Process:  actin filament bundle assembly; isotype switching; negative regulation of actin filament depolymerization; negative regulation of cell-cell adhesion mediated by integrin; negative regulation of peptidyl-serine dephosphorylation; positive regulation of actin filament bundle assembly; positive regulation of cytosolic calcium ion concentration; positive regulation of mast cell chemotaxis; regulation of protein localization
Reference #:  Q9UH65 (UniProtKB)
Alt. Names/Synonyms: FLJ39540; HSPC321; KIAA0640; SWAP switching B-cell complex 70kDa subunit; SWAP-70; SWAP70; Switch-associated protein 70; SWP70
Gene Symbols: SWAP70
Molecular weight: 68,998 Da
Basal Isoelectric point: 5.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SWAP-70

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene