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NFL
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. Belongs to the intermediate filament family. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal |
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Cellular Component:
axon; axon cytoplasm; cholinergic synapse; intermediate filament; neurofilament; neuromuscular junction; presynaptic intermediate filament cytoskeleton; Schaffer collateral - CA1 synapse
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Molecular Function:
identical protein binding; protein binding; protein-macromolecule adaptor activity; structural constituent of cytoskeleton
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Biological Process:
anterograde axonal transport; axonal transport of mitochondrion; axonogenesis; intermediate filament bundle assembly; intermediate filament organization; locomotion; microtubule cytoskeleton organization; motor neuron apoptotic process; negative regulation of motor neuron apoptotic process; negative regulation of neuron apoptotic process; neurofilament bundle assembly; neurofilament cytoskeleton organization; neuromuscular process controlling balance; neuron projection morphogenesis; peripheral nervous system axon regeneration; positive regulation of axonogenesis; postsynaptic intermediate filament cytoskeleton organization; postsynaptic modulation of chemical synaptic transmission; regulation of axon diameter; regulation of synapse maturation; retrograde axonal transport
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Reference #:
P02548
(UniProtKB)
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Alt. Names/Synonyms: 68 kDa neurofilament protein; Micro glutamic acid-rich protein; NEFL; Neurofilament light polypeptide; Neurofilament triplet L protein; NF-L; NFL
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Gene Symbols: NEFL
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Molecular weight:
62,646 Da
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Basal Isoelectric point:
4.59
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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