Rb-like 1 Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor. Belongs to the retinoblastoma protein (RB) family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; Tumor suppressor
Chromosomal Location of Human Ortholog: 20q11.23
Cellular Component:  nucleoplasm
Molecular Function:  promoter-specific chromatin binding; protein binding; transcription factor binding
Biological Process:  cell cycle; chromatin organization; negative regulation of cellular senescence; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of cell division; regulation of lipid kinase activity; viral process
Reference #:  P28749 (UniProtKB)
Alt. Names/Synonyms: 107 kDa retinoblastoma-associated protein; cellular protein 107; CP107; MGC40006; p107; pRb1; RBL1; retinoblastoma-like 1 (p107); Retinoblastoma-like protein 1
Gene Symbols: RBL1
Molecular weight: 120,847 Da
Basal Isoelectric point: 7.32  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Rb-like 1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein