Rb-like 1
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor. Belongs to the retinoblastoma protein (RB) family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Transcription, coactivator/corepressor; Tumor suppressor |
Chromosomal Location of human Ortholog: 20q11.23 |
Cellular Component:
chromatin; nucleoplasm; transcription regulator complex
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Molecular Function:
promoter-specific chromatin binding; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding
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Biological Process:
cell cycle; cell differentiation; chromatin organization; negative regulation of cellular senescence; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; regulation of lipid kinase activity
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Reference #:
P28749
(UniProtKB)
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Alt. Names/Synonyms: 107 kDa retinoblastoma-associated protein; cellular protein 107; CP107; MGC40006; p107; pRb1; RB transcriptional corepressor like 1; Rb-like 1; RBL1; retinoblastoma-like 1; retinoblastoma-like 1 (p107); Retinoblastoma-like protein 1
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Gene Symbols: RBL1
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Molecular weight:
120,847 Da
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Basal Isoelectric point:
7.32
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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