CHGA a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells and is a precursor to multiple biologically active peptides including vasostatin, pancreastatin, and chromostatin. Binds calcium with a low-affinity. Vasostatin negatively regulates angiogenesis and has antibacterial activity against some Gram-positive bacteria. Pancreastatin inhibits glucose induced insulin release from the pancreas. Chromostatin inhibits catecholamine release from chromaffin cells. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Secreted; Secreted, signal peptide; Vesicle
Chromosomal Location of Human Ortholog: 14q32.12
Cellular Component:  chromaffin granule; extracellular region; extracellular space; mast cell granule; perinuclear region of cytoplasm; secretory granule; transport vesicle membrane
Biological Process:  adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation; antimicrobial humoral response; defense response to fungus; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; innate immune response; killing of cells of other organism; mast cell activation; mast cell chemotaxis; mast cell cytokine production; mast cell degranulation; negative regulation of blood vessel diameter; negative regulation of catecholamine secretion; negative regulation of neuron death; organelle organization; positive regulation of cardiac muscle contraction; positive regulation of dense core granule biogenesis; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of relaxation of cardiac muscle; protein localization to secretory granule; regulation of blood pressure; regulation of the force of heart contraction
Reference #:  P10645 (UniProtKB)
Alt. Names/Synonyms: AL-11; betagranin (N-terminal fragment of chromogranin A); CgA; CHGA; chromogranin A (parathyroid secretory protein 1); Chromogranin-A; CMGA; EA-92; ER-37; ES-43; GR-44; GV-19; LF-19; Pancreastatin; parathyroid secretory protein 1; Pituitary secretory protein I; SP-I; SS-18; Vasostatin I; Vasostatin II; Vasostatin-1; Vasostatin-2; WA-8; WE-14
Gene Symbols: CHGA
Molecular weight: 50,688 Da
Basal Isoelectric point: 4.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB