RXRA Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes. Belongs to the nuclear hormone receptor family. NR2 subfamily. Highly expressed in liver, also found in lung, kidney and heart. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor
Chromosomal Location of human Ortholog: 9q34.2
Cellular Component:  chromatin; cytosol; mitochondrion; nucleoplasm; nucleus; receptor complex; RNA polymerase II transcription regulator complex; transcription regulator complex
Molecular Function:  DNA binding domain binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; enzyme binding; identical protein binding; ion binding; LBD domain binding; nuclear receptor activity; nuclear receptor binding; nuclear steroid receptor activity; nuclear vitamin D receptor binding; peptide binding; protein binding; retinoic acid binding; retinoic acid-responsive element binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; transcription coregulator binding; vitamin D response element binding; zinc ion binding
Biological Process:  anatomical structure development; cell differentiation; hormone-mediated signaling pathway; mRNA transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; peroxisome proliferator activated receptor signaling pathway; positive regulation of bone mineralization; positive regulation of cholesterol efflux; positive regulation of DNA-templated transcription; positive regulation of thyroid hormone mediated signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of transporter activity; positive regulation of vitamin D receptor signaling pathway; response to retinoic acid; retinoic acid receptor signaling pathway; steroid hormone mediated signaling pathway
Reference #:  P19793 (UniProtKB)
Alt. Names/Synonyms: FLJ00280; FLJ00318; FLJ16020; FLJ16733; MGC102720; NR2B1; Nuclear receptor subfamily 2 group B member 1; Retinoic acid receptor RXR-alpha; retinoid X nuclear receptor alpha; Retinoid X receptor alpha; retinoid X receptor, alpha; RXR-alpha; RXRA
Gene Symbols: RXRA
Molecular weight: 50,811 Da
Basal Isoelectric point: 7.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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