IL-1RA Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells. Belongs to the interleukin-1 receptor family. Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Receptor, cytokine
Chromosomal Location of human Ortholog: 2q11.2-q12.1
Cellular Component:  external side of plasma membrane; extracellular region; membrane; plasma membrane
Molecular Function:  interleukin-1 binding; interleukin-1 receptor activity; interleukin-1, type I, activating receptor activity; NAD(P)+ nucleosidase activity; NAD+ nucleotidase, cyclic ADP-ribose generating; platelet-derived growth factor receptor binding; protease binding; protein binding; transmembrane signaling receptor activity
Biological Process:  cell surface receptor signaling pathway; immune response; inflammatory response; interleukin-1-mediated signaling pathway; positive regulation of interleukin-1-mediated signaling pathway; positive regulation of neutrophil extravasation; positive regulation of T-helper 1 cell cytokine production; positive regulation of type II interferon production; regulation of inflammatory response; response to interleukin-1
Reference #:  P14778 (UniProtKB)
Alt. Names/Synonyms: antigen CD121a; CD121 antigen-like family member A; CD121A; D2S1473; IL-1R-1; IL-1R-alpha; IL-1RA; IL-1RT-1; IL-1RT1; IL1R; IL1R1; IL1RA; IL1RT1; interleukin 1 receptor alpha, type I; interleukin 1 receptor type 1; interleukin 1 receptor, type I; interleukin receptor 1; Interleukin-1 receptor alpha; Interleukin-1 receptor type 1; Interleukin-1 receptor type 1, membrane form; Interleukin-1 receptor type 1, soluble form; Interleukin-1 receptor type I; mIL-1R1; mIL-1RI; p80; sIL-1R1; sIL-1RI
Gene Symbols: IL1R1
Molecular weight: 65,402 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene