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IL-1RA
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells. Belongs to the interleukin-1 receptor family. Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.25; Membrane protein, integral; Receptor, cytokine |
| Chromosomal Location of human Ortholog: 2q11.2-q12.1 |
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Cellular Component:
external side of plasma membrane; extracellular region; membrane; plasma membrane
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Molecular Function:
interleukin-1 binding; interleukin-1 receptor activity; interleukin-1, type I, activating receptor activity; NAD(P)+ nucleosidase activity; NAD+ nucleotidase, cyclic ADP-ribose generating; platelet-derived growth factor receptor binding; protease binding; protein binding; transmembrane signaling receptor activity
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Biological Process:
cell surface receptor signaling pathway; immune response; inflammatory response; interleukin-1-mediated signaling pathway; positive regulation of interleukin-1-mediated signaling pathway; positive regulation of neutrophil extravasation; positive regulation of T-helper 1 cell cytokine production; positive regulation of type II interferon production; regulation of inflammatory response; response to interleukin-1
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Disease: Chronic Recurrent Multifocal Osteomyelitis 3
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Reference #:
P14778
(UniProtKB)
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Alt. Names/Synonyms: antigen CD121a; CD121 antigen-like family member A; CD121A; D2S1473; IL-1R-1; IL-1R-alpha; IL-1RA; IL-1RT-1; IL-1RT1; IL1R; IL1R1; IL1RA; IL1RT1; interleukin 1 receptor alpha, type I; interleukin 1 receptor type 1; interleukin 1 receptor, type I; interleukin receptor 1; Interleukin-1 receptor alpha; Interleukin-1 receptor type 1; Interleukin-1 receptor type 1, membrane form; Interleukin-1 receptor type 1, soluble form; Interleukin-1 receptor type I; mIL-1R1; mIL-1RI; p80; sIL-1R1; sIL-1RI
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Gene Symbols: IL1R1
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Molecular weight:
65,402 Da
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Basal Isoelectric point:
8
Predict pI for various phosphorylation states
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CST Pathways:
NF-kB Signaling
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