Rb Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. Belongs to the retinoblastoma protein (RB) family. Expressed in the retina. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor
Chromosomal Location of human Ortholog: 13q14.2
Cellular Component:  nucleoplasm; nucleus; PML body; Rb-E2F complex; spindle; SWI/SNF complex
Molecular Function:  androgen receptor binding; disordered domain specific binding; DNA binding; DNA-binding transcription factor activity; identical protein binding; importin-alpha family protein binding; kinase binding; phosphoprotein binding; protein binding; proximal promoter sequence-specific DNA binding; transcription coactivator activity; transcription factor binding; ubiquitin protein ligase binding
Biological Process:  androgen receptor signaling pathway; aortic valve morphogenesis; cell cycle arrest; cell division; cellular response to xenobiotic stimulus; chromatin remodeling; digestive tract development; enucleate erythrocyte differentiation; G1/S transition of mitotic cell cycle; glial cell apoptotic process; hepatocyte apoptotic process; maintenance of mitotic sister chromatid cohesion; mitotic cell cycle checkpoint; myoblast differentiation; negative regulation of apoptotic signaling pathway; negative regulation of cell cycle; negative regulation of cold-induced thermogenesis; negative regulation of DNA-binding transcription factor activity; negative regulation of epithelial cell proliferation; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; negative regulation of inflammatory response; negative regulation of myofibroblast differentiation; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; negative regulation of smoothened signaling pathway; negative regulation of tau-protein kinase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transcription involved in G1/S transition of mitotic cell cycle; negative regulation of transcription, DNA-templated; neuron apoptotic process; neuron maturation; positive regulation of collagen fibril organization; positive regulation of extracellular matrix organization; positive regulation of macrophage differentiation; positive regulation of mitotic metaphase/anaphase transition; positive regulation of transcription by RNA polymerase II; positive regulation of transcription regulatory region DNA binding; positive regulation of transcription, DNA-templated; protein localization to chromosome, centromeric region; Ras protein signal transduction; regulation of cell growth; regulation of centromere complex assembly; regulation of cohesin loading; regulation of lipid kinase activity; regulation of mitotic cell cycle; regulation of transcription, DNA-templated; sister chromatid biorientation; skeletal muscle cell differentiation; striated muscle cell differentiation; tissue homeostasis; viral process
Disease: Bladder Cancer; Osteogenic Sarcoma; Retinoblastoma; Small Cell Cancer Of The Lung
Reference #:  P06400 (UniProtKB)
Alt. Names/Synonyms: exon 17 tumor GOS561 substitution mutation causes premature stop; GOS563 exon 17 substitution mutation causes premature stop; OSRC; p105-Rb; p110-RB1; pp110; PPP1R130; pRb; prepro-retinoblastoma-associated protein; protein phosphatase 1, regulatory subunit 130; Rb; RB transcriptional corepressor 1; RB1; retinoblastoma 1; retinoblastoma suspectibility protein; Retinoblastoma-associated protein
Gene Symbols: RB1
Molecular weight: 106,159 Da
Basal Isoelectric point: 8.13  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  Protein Acetylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA