ECEL1 May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides. Belongs to the peptidase M13 family. Highly expressed in the CNS, in particular in putamen, spinal cord, medulla and subthalamic nucleus. A strong signal was also detected in uterine subepithelial cells and around renal blood vessels. Detected at lower levels in amygdala, caudate, thalamus, pancreas and skeletal muscle. Detected at very low levels in substantia nigra, cerebellum, cortex, corpus callosum and hippocampus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.24.-; Membrane protein, integral; Protease
Chromosomal Location of human Ortholog: 2q37.1
Cellular Component:  plasma membrane
Molecular Function:  metal ion binding; metalloendopeptidase activity; metallopeptidase activity
Biological Process:  neuropeptide signaling pathway; protein processing; respiratory system process
Disease: Arthrogryposis, Distal, Type 5d
Reference #:  O95672 (UniProtKB)
Alt. Names/Synonyms: DA5D; damage induced neuronal endopeptidase; DINE; ECEL1; ECEX; endothelin converting enzyme like 1; endothelin converting enzyme-like 1; Endothelin-converting enzyme-like 1; X converting enzyme; XCE; Xce protein
Gene Symbols: ECEL1
Molecular weight: 87,791 Da
Basal Isoelectric point: 6.58  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein