PSD-93 Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. Belongs to the MAGUK family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1q32
Cellular Component:  anchored component of postsynaptic density membrane; axon cytoplasm; basolateral plasma membrane; cell junction; cytoplasm; dendrite; glutamatergic synapse; juxtaparanode region of axon; membrane; neuromuscular junction; neuron projection; neuronal cell body; nucleus; plasma membrane; postsynaptic density; postsynaptic density membrane; postsynaptic membrane
Molecular Function:  ionotropic glutamate receptor binding; kinase binding; PDZ domain binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein phosphatase binding; structural constituent of postsynaptic density
Biological Process:  anterograde axonal protein transport; cell-cell adhesion; cellular response to potassium ion; chemical synaptic transmission; establishment or maintenance of epithelial cell apical/basal polarity; maintenance of postsynaptic density structure; negative regulation of phosphatase activity; neuronal ion channel clustering; neurotransmitter receptor localization to postsynaptic specialization membrane; receptor clustering; receptor localization to synapse; retrograde axonal protein transport; sensory perception of pain
Reference #:  Q63622 (UniProtKB)
Alt. Names/Synonyms: Channel-associated protein of synapse-110; Chapsyn-110; discs large homolog 2; discs, large homolog 2 (Drosophila); Disks large homolog 2; Dlg2; Dlgh2; Postsynaptic density protein PSD-93; PSD-93; synaptic density protein PSD-93
Gene Symbols: Dlg2
Molecular weight: 94,934 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene