PSD-93 Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. Belongs to the MAGUK family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 11q14.1
Cellular Component:  axon cytoplasm; cytosol; glutamatergic synapse; juxtaparanode region of axon; membrane; plasma membrane; postsynaptic density
Molecular Function:  guanylate kinase activity; kinase binding; protein binding; structural constituent of postsynaptic density
Biological Process:  anterograde axonal protein transport; cellular response to potassium ion; GDP metabolic process; GMP metabolic process; maintenance of postsynaptic density structure; MAPK cascade; negative regulation of phosphatase activity; neurotransmitter receptor localization to postsynaptic specialization membrane; regulation of NMDA receptor activity; retrograde axonal protein transport; sensory perception of pain
Reference #:  Q15700 (UniProtKB)
Alt. Names/Synonyms: Channel-associated protein of synapse-110; channel-associated protein of synapses, 110kDa; Chapsyn-110; discs large MAGUK scaffold protein 2; discs, large homolog 2 (Drosophila); discs, large homolog 2, chapsyn-110; Disks large homolog 2; DKFZp781D1854; DKFZp781E0954; DLG2; FLJ37266; MGC131811; Postsynaptic density protein PSD-93; PPP1R58; protein phosphatase 1, regulatory subunit 58; PSD-93; PSD93
Gene Symbols: DLG2
Molecular weight: 97,552 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein